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Building stimuli-responsive primitive cells – ResponCell
Despite being self-sustaining units of life, cells do not live in isolation. Due to selective membrane permeability, cell survival depends on the ability of membrane-bound biological machinery to regu
mGluR5 nanobodies as innovative therapeutic tools for Alzheimer’s disease – NanoThALZ
Metabotropic glutamate receptor 5 (mGluR5) is highly expressed in brain regions responsible for memory and learning. Aberrant mGluR5 signaling and associated synaptic failure are now considered as an
PBP2/MreC: an ideal target to identify new antibacterial agents – BacWallScreen
The peptidoglycan, a heteropolymer and major component of the bacterial cell wall, is essential for cell integrity. It surrounds completely the cell and its synthesis is coordinated with cell growth a
More Robust phenoxy-amidines (FA) Ligands for better catalytic performance – MORFAL
Phenoxyimines (FI) and Salen are ubiquitous ligands that are widely used, particularly in organometallic catalysis, with various industrial applications. However, one inherent drawback of their struct
Manganese-catalyzed Intermolecular Alkene Carbofunctionalization – MANIAC
Decades of improvement in the cross-coupling arena have provided a highly modular toolkit for bond construction in organic synthesis. In addition, the introduction of an alkene as a third component ha
Micro- Magnetic-Manipulation of Multiblock Copolymers – MANIOC
Since the emergence of the nanotechnologies era in the 80s, block copolymers are frequently used to design host patterns allowing to control the structure of inorganic nanoparticles assemblies. The pi
Correlated quantum-chemistry methods for solids – CLIFFORD
The CLIFFORD project aims to describe crystalline solids with correlated quantum-chemistry approaches such as configuration interaction and coupled cluster theory. These methods have already been appl
Microtubule methylation by SET domain protein methyltransferases – MICROMETHYL
The alpha-beta-tubulin heterodimer protein is the microtubule building block. The hydrolysis of the GTP molecule bound to the beta subunit that accompanies assembly makes microtubules intrinsically dy
Biocatalysis on phase boundary: modelling and design of enzymatic gas-diffusion electrodes – THREENZY
Being efficient and selective, enzymatic biocatalysts composed of abundant elements may successfully replace abiotic heterogeneous catalysts in sustainable energy applications such as fuel cells, bior
Immersive Collaborative Analysis foR Education – ICARE
In this project, we explore the use of immersive technologies for collaborative learning. First in fully virtual reality environments and then in a hybrid one which includes different types of devices