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Structure and impact of lipids on the 5-HT2A-mGlu2 heteromer, a schizophrenia drug target – Schizoceptor
metabotropic glutamate mGlu2 and the serotonin 5-HT2A were found to interact and form a heteromer in schizophrenic [...] little is known on the molecular mechanisms of 5-HT2A-mGlu2 heteromer formation and its functional interplay [...] fluorescence to understand how lipids and 5-HT2A-mGlu2 modulate each other's function.
Optimization of a flexible technological chaine of CO2/H2O co-electrolysis and CO-hydrogenation into synthetic methane – CHOCHCO
and CO2 into a syngas made of H2 and CO) 2) a catalytic methanation block 3) and probably, a methane [...] project deals with the issue of CO2 value chain and with the development of a novel family of solutions for [...] this solution enables to build a carbon circular economy by enhancing CO2 value. The “Power to Methane”
New Antiviral approach against SARS-CoV2 by Targeting the RNA helicase DHX9, a cofactor of SARS COV-2 – NAT_DHX9
Dr. Briant, we set-up a model of SARS-CoV-2 infection using Vero E6 and A549-ACE2 cells. In our preliminary [...] consider DHX9 as a potential therapeutic target for the development of anti-SARS-CoV-2 molecules. In c [...] of the SARS-CoV-2 virus and that our DHX9 inhibitors demonstrated strong anti-SARS CoV-2 antiviral properties
Inhibition of SARS-Cov2-S - ACE2 interaction AS A THERAPEUTIC TARGET – ACE2-S-Cov
interacts with angiotensin-converting enzyme 2 (ACE2). ACE2 is an essential component of the renin–angiotensin [...] the effect of a series of patented molecules targeting the SARS-CoV-2 -S protein / ACE2 interaction. It [...] severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become pandemic, in the absence of an
Analysis of the spatio-temporal variability of pCO2 and air-sea flux of CO2 over the global coastal ocean during the last two decades: a satellite approach – CO2COAST
carbon fluxes are such, that the CO2 flux in the coastal margins remains a poorly constrained term in global [...] objectives of CO2COAST are to estimate, for the first time, the global coastal waters CO2 flux from satellite [...] to the estimation of pCO2 from space, although convenient to develop, present a regional character that
A2A receptors and Tauopathy – ADORATAU
of interest in a therapeutic perspective. With this regards, adenosine A2A receptors (A2AR) are targets [...] al data linking A2AR to Tau pathology. Indeed, global genetic blockade of A2ARs in a Tau transgenic mouse [...] showing that A2A receptor expression is increased in the brain of AD patients. However, A2ARs are not only
Synthesis and applications of planar chiral photoredox catalysts based on a [2.2]paracyclophane scaffold – PhotoChiraPhane
As a consequence of their rigid three-dimensional structure, deck-substituted [2.2]paracyclophanes (pCps) [...] transformations. The rigid [2.2]paracyclophane unit will serve two key functions: a) ensure close proximity [...] (the scientific coordinator, and a member of her team), together with a PhD student, who will be hired
Targeting A2A receptor in autism: single domain antibodies for direct inhibition or antagonist vectorization – A2utismAb
Among adenosine receptors, the A2A receptor (A2AR) is a G-protein coupled receptor (GPCR) that receives [...] receives raising attention as a therapeutic target in multiple pathologies. Brain A2AR expression is quasi [...] either for the target or for a particular tissue, allowing a better efficacy and a reduction of side effects: