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MIGAT will gather resources from the Liryc Institute, the Inria and the University Hospital of Bordeaux to develop a computer-based solution with high expected impact on the daily management of cardiac electrical disorders. The research program will benefit from the MUSIC equipment recently funded a

Inflammatory bowel disease (IBD) including Crohn’s Disease (CD) and Ulcerative Colitis (UC) are chronic diseases evolving in a relapsing-remitting pattern, characterised by an uncontrolled over-activation of the intestinal immune system. Its frequency is increasing over the world and the lifetime ri

Parkinson’s Disease (PD) is a progressive disorder, commonly characterised by a loss of pigmented neurons within the substantia nigra pars compacta that send axonal projection to the striatum, and in particular the caudate and putamen, resulting in decreased dopamine availability. Clinically, PD is

Several methods are used during presurgical evaluation. Intracerebral EEG (or stereotactic EEG, SEEG) is an invasive techniquethat permits recording directly within the brain. In contrast, electrophysiology (Magnetoencephalography MEG, and Electroencephalography, EEG) constitute non-invasive ways to

Acute respiratory distress syndrome (ARDS) is a major cause of respiratory failure and death and is characterized by lung epithelial and endothelial injury. Alveolar fluid transport function is critical for its resolution, but therapeutic approaches are limited. A better understanding of the pathoph

Cornea grafts: Currently, preoperative evaluation of corneal grafts is limited, and the extent to which their histological characteristics influence the long-term outcome of the graft remains unknown. We expect that FFOCT evaluation of donor corneas will become standard procedure for eye banks, and

Inborn enzyme defects of fatty acid ß-oxidation (FAO) form a group of genetic disorders associated to life-threatening pediatric presentations, or to milder phenotypes with later onset and severity. Advances in diagnosis revealed a large number of disease-causing genes , and a continuous increase in

The main aim is to assess the level of neuroinflammation in AD subjects estimated with Binding Potential of [18F]DPA-714 and its relationship with the kinetics of cognitive decline (24-month follow-up period). Additional aims : to assess the relationship between the uptake of [18F]DPA-714 and 1/ co

We have already showed: 1) the efficacy of a phosphorus-based dendrimer (so-called the ABP dendrimer) in mouse models of Rheumatoid Arthritis and Multiple Sclerosis (chronic inflammatory diseases of auto-immune origin), 2) general and immunological safety of the ABP dendrimer in a non-human primat

In the European Union and the United States of America, cardiovascular diseases are responsible for 40% of the total mortality, the vast majority of those deaths being caused by coronary artery disease and its direct clinical consequence, the rupture of a vulnerable atherosclerotic plaque (VP). Howe

Necrotizing enterocolitis (NEC) is a devastating digestive disorder affecting preterm neonates with high morbidity and mortality. If its pathophysiology remains unclear , bacterial intestinal colonization is a known risk factor. NEC bacterial involvement sems be link to the colonic bacteria fermenta

Our project bridges this important gap in a multidisciplinary approach (diabetology-transplantation medicine/biology-electrophysiology/microelectronics) from bench to bed and bed to bench implying two research groups from CNRS laboratories (Bordeaux), two clinical groups in France (Grenoble, Montpel

The prevailing view in telomere epidemiology is that leukocyte telomere length (LTL) is associated with atherosclerosis and accelerated aging since it serves as a biomarker of the cumulative burden of inflammation and oxidative stress during adult life. Our recent results however, indicate that telo

The objective of this project is to promote the use of results already achieved through a work of fundamental nature which has allowed to obtain the proof of concept and to obtain a patent application (PCT and national phase) in order to achieve the effective promotion of the project after funding.

Rheumatoid arthritis (RA) is a systemic disease, which mainly targets joints and results in osteoarticular destruction and serious disability. When clinical symptoms (painful and swollen joints) occur, the innate and adaptive immune responses against self antigens have already been largely amplified

GBS (Streptococcus agalactiae) is a Gram-positive encapsulated commensal bacterium of the human intestinal flora which is also present in the vaginal flora of 30% of healthy women. However, when neonates are infected through their mother during delivery, it can turn into a highly pathogenic bacteriu

Apparently balanced chromosomal rearrangements (ABCR) associated with intellectual disability and / or malformations are rare events but are challenging for genetic counseling. The phenotype may be secondary to gene disruption by the breakpoint. However, breakpoints characterization by conventional

The immune system is a privileged organ to study the DNA damage response (DDR), as it is the site of an important genetic plasticity as part of its program of development and maturation. Many DNA modifications are indeed introduced in the genome of B and T lymphocytes during programmed molecular pro

The goal is tu use a mouse model to establish whether, like in immune thrombocytopenia in humans, B-cell depletion induces the emergence of long-lived plasma cells in the spleen. We will establish the survival factors and the cellular components of the plasma cell niche in the mouse spleen, and stud

Recent developments in basic biology open new avenues to the development of biomarker sets that could predict GVHD severity and prognosis that could be tested and validated through well-designed multicenter clinical trials. The main goal of this project is to further our understanding of the patho

Patients affected by ectodermal dysplasia syndrome linked to p63 (EEC) suffer from limb and skin defects, associated with progressive opacification of the cornea that leads eventually to loss of vision.There is no available treatment today. Our network has demonstrated that patient fibroblasts, repr