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Fractioning the phenotype of the biology of the visual Conscious networks. – Phenotypes
The ANR Phenotype has for objective to explore the fundamental elements that constitute our consciousness. The main hypothesis is that structural connectivity in the brain is the elemental base of high cognitive function built from the interaction between primary cognitive processes, with at the top
Cortical processing of visual space : retinotopy or “perceptopy” ? – PERCEPTOPY
This project aims to better understand the nature of representations of visual space generated in the brain. In particular, we question the widely held view that these representations reflect the objective properties of the images formed on the retinas. In view of recent data , we hypothesize that t
Role of the transcription factor NeuroD2 in synaptic integration in the postnatal brain – SynD2
Neurogenesis persists lifelong in two regions of the mammalian brain: the hippocampal dentate gyrus and the olfactory bulb. In the latter region different types of neurons are continuously generated, from neural stem cells located a long distance away, in the periventricuar zone (PVZ). New bulbar ne
Scaffold remodeling: Dynamics and function of mGlu5 receptosome in synaptic plasticity – SYN CITY
The main objective of this study is to understand how the function of a receptor is acutely and dynamically specified in time and space in the neuron. By attributing one specific function to each individual interactions of the receptor, we will be able to modify one single deficient function of the
MEsopontine CONtrol Of Stress – MECONOS
The main scientific objective of this ANR is to isolate, amongst the multisynaptic neural circuits mediating stress effects, the key system that boosts dopamine neurotransmission within the reward system and ultimately leads to a persistent social aversion. Consequences of the selective inactivation
The ins and outs of spinal cholinergic interneurons: a keystone for cholinergic analgesia – ACh-Spinal-Pain
Chronic pain is a devastating and widespread problem, and the existing treatments, including opioids, have limited efficacy (especially in the long term). In the look for alternative therapies, our project proposes to characterize an endogenous mechanism of pain flux control at the spinal cord level
Functional Examination of a Reciprocal Neural Circuit between the Hypothalamus and Hippocampus – HYPO-HIPPO
The ability to form memories and recall past events is a profoundly important ability for many aspects and levels of life. In mammals, it is firmly established that the hippocampus is as essential structure for long-term memory formation. Furthermore, due to its relatively simple laminar organizatio