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Fate and effects of selected persistent organic pollutants (PCBs, PBDEs) on fish reproduction, development and survival of the progeny. – Fish'N'POPs
Aquatic ecosystems in general and littoral areas in particular are submitted to ever growing anthropic pressures. Coastal ecosystems have a high economical and ecological value as they host a large number of species for some parts of or all their life. Such species are thus exposed to anthropogenic
From the characterization of factors determining paralytic toxin (PST) accumulation by the oyster Crassostrea gigas to risk assessment for human health within its social context – ACCUTOX
Harmful Algal Blooms (HABs) have major socio-economic and ecological impacts, by making the cultivated and/or fished shellfish unsuitable for consumption, by disrupting the balance of populations, by causing mortality or recruitment failures, and deeply disturbing human activities profoundly linked,
Synergistic and toxic cocktail effects of low dose endocrine disruptors – TOXSYN
Most current knowledge of endocrine disrupting chemicals (EDC) action is derived from data sets that use single molecule exposure, with few studies taking into account the more realistic situation where humans and wildlife are simultaneously and chronically exposed to low doses of multiple EDCs. The
Chronic exposure to antibiotics and metals in soil : impact on microbial processes including antibiotic resistance dynamic – CEMABS
The intensive use of antibiotics in human and veterinary medicine, to protect plants and fruits, and to promote animal growth in livestock production facilities led, directly or through amendments, to the widespread dissemination of antibiotics in the environment. To cope with the toxic effect of an
Occurrence and Effect of environmental progesterone receptor ligands on fish reproduction and neurodevelopment – PROOFS
PROOFS is an interdisciplinary project aiming at studying the potential impact of environmental progestins on the neurodevelopment and on the reproduction in fish but also at investigating the progestative activities of environmental samples and identifying the compounds responsible these biological
Prostate exposition to chlordecone and molecular disruption related to tumor promotion. – CHLORPROST
Chlordecone (CLD) is an organochlorine insecticide that was used on the banana plantations of the French West Indies from 1973 to 1993. Because of its low dissipation in the environment, it has now caused long-term contamination of the environment, soil and water, and local agriculture and fisheries
Impacts of chronic intoxication by Bt k bioinsecticides on the intestinal homeostasis and the immune response: from insects to mammals – ImBio
Cry toxins produced by Bacillus thuringiensis (Bt) are becoming widely used worldwide as bioinsecticides or in genetically modified crops (GMC) to fight lepidopteran, coleopteran and dipteran pests in organic farming, forestry and mosquito control. Moreover, with recent incentives, such as Plan Ecop
Environmental impact of synthetic and natural ß-triketone herbicides: detection, microbial adaptation, biodegradation and toxicity. – TRICETOX
Most agricultural production relies on the use of chemicals to maintain high crop yields. The use of these chemicals in farming practices is viewed as an integral part of the success of the intensive farming. However, most of the pesticides applied to agricultural lands may affect non-target organis
Responses of pelagic microorganisms to contamination by polluted sediments – RISCO
It is now well recognized that the risk of environmental contamination by chemical pollutants is particularly high in coastal environments where past, present and forecasted demographic increases, are amplifying the pressures in these ecosystems. Unraveling the links between contamination pressure a
Lakes of the Altiplano (Bolivia): in situ exploration of the (a)biotic Processes controlling the Aquatic biogeoCHemistry of Mercury At the Molecular and Isotopic scAle. – LA PACHAMAMA
To study the environmental chemistry and advanced transformations of contaminants, combined molecular and multi isotopic signatures should provide new information to better constrain their biogeochemical fate and ecotoxicological impact. The compound specific isotopic composition can also be relevan
Nanomaterials across a salinity gradient: exposure and ecotoxicological effects within a life cycle perspective (production, usage, end of life) – nanoSALT
The current and foreseen applications of engineered nanomaterials (ENMs) embrace a wide range of technological domains and represent a significant economical fact. From 2006 to 2010 the number of nano-enabled products evolved from approximately 50 to more than 1300. Still now, a large number of unce
Impact of antenatal exposure to pesticides on neurophysiological functions (sleep, respiration) of preterm neonates – PHYSIOMECO
Although the health effects of pesticides in man following acute intoxication are well known, little is known about the effects of chronic low-dose exposure. Furthermore, the paradigm concerning the dose-effect relationship is also increasingly contested, as the time of exposure now appears to be a
Effects of Atmospheric Pollution on Placental function and post-natal development – EPPAP
The DOHaD (Developmental Origins of Health and Disease) hypothesis states that exposure to exogenous stressors during the developmental period can alter fetal development and increase the risk of diseases in childhood and later. Alterations of epigenetic marks constitute one mechanism whereby these
Role of autophagy in the respiratory effects of nanoparticles – Nanautophagie
Although great advancements, including in the medical field, can be predicted thanks to the development of nanotechnologies, concerns are growing because of the potential effects of manufactured nanoparticles (MNP) on human health. This is particularly true for the respiratory tract, because it repr
Impact of environmental chemicals on the mechanisms of disease progression of liver steatosis – STEATOX
Several studies are pointing out that western lifestyle (high-fat diet, alcohol consumption, cigarette smoking) cannot explain by itself the increasing incidence of cancers, especially of hepatocellular carcinoma (HCC). Obesity, which increased from 8 % in 1997 to 14 % in 2009 in the French populati
Cadmium and Diabetes – CADMIDIA
The project Cadmidia aims at understanding the relationship between low level exposure to the widespread contaminant, cadmium, and dysfunction of pancreatic beta cells, which is a strongly contributing factor in the development of type II diabetes. Food contamination by cadmium and occurrence of typ
Development of an integrative modelling approach to evaluate the human foetal internal exposure to a contaminant, applied to Bisphenol A as a probe – Modelexpo
The exposure to xenobiotics during prenatal life is a major concern for toxicologists. Xenobiotic exposure of the foetus during critical windows of development have repeatedly been suggested to be involved in the onset of a variety of biological effects later in life, even when exposure occurs at lo
Vulnerability and adaptability of the last population of the European Sturgeon (Acipenser sturio) to environmental stress factors : temperature, oxygen, pollutants. – SturTOP
The European sturgeon (Acipenser sturio) is the most endangered migratory diadromous fish in Europe. The Garonne-Dordogne basin is host to the last population of this species. Pollution and global warming represent probable threats for this endangered species. SturTOP is a multidisciplinary research
Contribution to the Human exposure assessment related to substitutes and derivatives of Bisphenol A and to the associated hazard characterisation. – NEWPLAST
The present project focuses on substitutes and derivatives of bisphenol A (BPA) which are used in the manufacture of polycarbonate and epoxy resins, including food contact materials. Indeed, a growing attention has been paid to BPA in recent years, giving rise to an intense debate concerning its end
Function of the Ah Receptor and its ligands in the nervous system – TOXAhBRAIN
Environmental pollution represents a growing threat for industrial and third world countries. It can lead to a disruption of ecosystem balance and has been partly associated with several major human diseases including asthma, diabetes or cancer. Environmental pollutants include numerous chemical fam