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Raman qualitative and quantitative descriptors of dry skin diseases : Cutaneous hydration Anomalies - a Raman Evaluation – CARE
The “dry skin” holds a dominating place in dermatology and in cosmetic applications. Skin dryness will be for the former, a discomfort due to the ageing, resulting from climatic effects or sun exposures, whereas for the latter the clinical sign of an ill-defined pathogenic dysfunction, for instance
Light Induced Cell Organization and Polarity – LICOP
- - - - The cell architecture and dynamics are controlled by a complex molecular circuitry able to process information from environmental cues in order to drive the cell into functional states accordingly. For instance, cells get polarized as they migrate or divide. To do so, they have to amplify lo
Genetically encoding chemical probes in ligand-gated ion channels – ChemProbe
The chemical synapse plays a central role in communication between neurons. Ligand-gated ion channels responsible for synaptic transmission were discovered more than four decades ago and have attracted much attention in neuroscience. Devastating neurological diseases arise when these protein recep
Cell sensitivity to the elastic properties of the extracellular matrix : from single cell to collective response to 2D or 3D spatial modulations of the rigidity. – ModElast
The discovery that cells sense and respond to the mechanical properties of the extracellular matrix has opened great opportunities in tissue bioengineering: cell localization or guidance, cell sorting for medical diagnosis, or patterning of selected cell types through rigidity-induced selective diff
Chemo-enzymatic Design of Heparan sulfate oligosaccharide libraries; Evaluation of protein HS binding specificities – HepLibScreen
Heparan Sulphate (HS) are sulphated polysaccharides ubiquitously present at higher eukaryotes cell surfaces and extracellular matrices. They participate in essential biological processes such as development, inflammatory responses, cell migration, blood coagulation. They are also used by pathogens d
Develop and explore new spinning micro-NMR detector for metabolomic study of mass-limited biopsies – HRMACS
Nuclear Magnetic Resonance (NMR) has already proven to be a tremendous tool in –omics studies of Systems Biology. Its major weakness is the low detection sensitivity, rendering the analysis of microscopic quantities impractical and often impossible. The use of ultra-high field spectrometers seems a
Microbubbles Ultrasound Super-Localization Imaging – MUSLI
Based on the simple fact that a cloud of randomly distributed microbubbles can act as distinct acoustic sources detected sequentially when imaged at ultrafast frame rates, sono-activated ultrasound localization microscopy can image micro-flow with a resolution and an accuracy up to 13 times the diff
Dynamic of cell mechanotransduction – DOCM
Cells ability to sense the mechanical properties of their microenvironment is a critical feature for tissue homeostasis (Jaalouk and Jan Lammerding 2009). Current evidence makes a strong case for a bidirectional relationship between integrin-mediated adhesion and mechanical forces genesis in that pr