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Characterization of the role of the balance phosphorylation/O-GlcNAcylation in the cellular regulation of protein synthesis in skeletal muscle – MYOSIGNAL
Skeletal muscle atrophy constitutes a real deal of public health. Muscle atrophy could be consecutive to common health pathologies such as cancer, AIDS or type II diabetes, but could also results from ageing, physical inactivity, immobilization, or spinal cord injuries. Muscle atrophy results from
Structural and functional relationships between the NS5A and NS5B Hepatitis C Virus proteins and the host Cyclophilin A. – StruFunc5A5B
Hepatitis C virus (HCV) is a RNA virus by which about 180 million people are chronically infected worldwide. The current treatment has a limited efficacy and leads to undesirable side effects. To develop new antiviral molecules, a better understanding of HCV and its interactions with cellular factor
Structure and function of ribonucleoprotein complexes assembly factors involved in human pathologies. – RNPgenesis
Molecular complexes are key players of cell life, and mutations in human proteins involved in the biogenesis or the deregulation of these complexes are often associated with genetic diseases or cancer. This project addresses the study of different assembly factors involved in human diseases, such as
‘Trans AT’ polyketide synthases (PKSs): studies of the mode of interaction between catalytic domains and their carrier protein-bound substrates (in cis/trans) – PKS-PPIs
An established approach to generating new polyketide structures is by altering the complex enzymes that assemble them, the polyketide synthases (PKS). But, in order to improve our ability to productively modify these systems, we need to determine how they work on the molecular level. Our aim, theref
Interference of para-aminobenzoic acid with Coenzyme Q metabolism in mammals : molecular causes, physiological consequences and biosynthesis of CoQ analogues. – pABACoQ
N-DMQ is a structural analogue of coenzyme Q formed when mammalian celles are cultured in the presence of pABA. Since pABA is used as a food supplement, we propose to study the functionality of N-DMQ in the respiratory chain and to assess its capacity to form or detoxify reactive oxygen species in
Genome mining of Trojan horse antibiotics: a combined chemical, biosynthetical and enzymological study – GenoTrojan
Bacterial resistance to existing antibiotics remains a major health concern. There is an urgent need for discovery of novel antibiotics. Some Bacteria utilise an elegant “Trojan horse“ strategy to fight against their competitors. They secrete small molecules which possess structural motifs in disgui