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living under stretch : from single cells to tissue – LuSt
A compléter A compléter A compléter A compléter Living organisms are sensitive to the mechanical environment and adapt their activity in response to solicitations. Specifically, embryogenesis involves dynamical changes that create the physical shape of the embryo, which show both as individual cell
Modelling of protein hydration water for small-angle scattering – HYDROSAS
This ANR project aims at developing an accurate description of the protein hydration shell. The experimental results will be compared with existing software and, if needed, new programs will be developed for the scientific community. The project is in its initial phase (6 months) with the first expe
Mechanics of blebbing cell motility – BlebMechanics
Cell motility is at the heart of many fundamental biological processes ranging from development over the immune response to the metastatic potential of cancer cells. Cell motility is divided in two different types, the mesenchymal, or gliding motility type, and the amoeboid, or blebbing motility typ
Exploring the yeast cell wall organization at the nanoscale by combining biomolecular, biochemical and biophysical approaches – AFMYST
This transdisciplinary project, AFMYST, will need skills in biology, chemistry and physics. The biological questions concern the yeast (Saccharomyces cerevisiae) cell wall organization and morphogenesis. The yeast cell wall has essentially been studied from a biochemical or molecular biology perspec
Singlet oxygen: from damage to proteins to the development of biosensors and generators – SOxygen
Singlet Oxygen (SO) is, in physiological conditions, one of the most elusive reactive oxygen species (ROS). Although its physics and chemistry have been intensively studied over the last three quarters of century, providing it with a defining role in chemical synthesis, its involvement in biological
Extracorporeal ThromboLysis using multifrequency Ultrasound – ULysSE
Current methods for the treatment of thrombosis have made great progress over the past twenty years, but deficiencies remain, despite everything: interventional techniques (thrombectomy, bypass) are invasive and require a specific equipment and experienced staff; alternative techniques use thromboly
A new Fragment-based Approach for inhibition of hk3 and matriptase, two up-regulated serine proteases implicated in tumor progression – FragSPIN
The modern-day approach to cancer management consists primarily of surgery, radiation therapy and chemotherapy, in varying combinations. Although surgery and radiation therapies effectively control many cancers at the primary site, the development of metastatic disease signals a poor prognosis. Most
Magnetic patterning and mechanically induced differentiation of stem cells. A novel approach towards tissue engineering. – MagStem
The project aimed at investigating the influence of controlled forces on cell differentiation with the purpose of tissue formation. The idea was to develop innovative approaches that will allow - to modulate the organization of stem cells assemblies, and to apply forces during the different differen
Aspects coopératifs de la régulation des sidérophores – COOPIRON
Microbial populations are considered as the sum of their individuals. Our project aims at measuring the interactions between individuals and at understanding how these interactions may modify the evolutionary dynamics of the global population. More specifically, we are interested in the mechanisms t