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Synthesis, characterization and Optical measurements of Chiral Spin-Transition compounds – CHIROTS
Molecular magnetism has drawn much interest these last 20 years particularly because of the possibility of using designed molecular precursors to obtain controlled geometries and properties. Spin crossover is a much studied phenomenon given its potential applications in data storage or thermo- or pi
Development of iron-based hydroamination catalysts for the cyclisation of primary and secondary aliphatic amines – DHAMFER
The need to develop new and more viable for the production of nitrogen molecules technologies has never been as high as these days. In this context, the direct addition of a simple amine onto a non-activated carbon-carbon double bond, the so-called hydroamination reaction, is a very promising approa
Targeting of oncogenic microRNAs : toward new chemotherapies – CImiR
MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that regulate gene expression at the post-transcriptional level. Accumulating evidence indicates that miRNAs are aberrantly expressed in a variety of human diseases including cancer, immune disorders and cardiovascular path
Chiral zwitterionic aryl-group surrogates for asymmetric catalysis – ChirASCat
Whereas several privileged, efficient, chiral ligand classes are well established, the conversion of an achiral catalytic system into its chiral version remains not straightforward. Indeed, the structural changes often lead to a strong reorganization of the coordination sphere and thus to a decrease
64Cu radiolabeled nanomaterials for diagnostic and radiotherapy – Copper nano-pincers
Each year, cancer affects approximately 3.2 million Europeans and no currently used medical imaging technique can establish an accurate diagnosis at an early stage of the disease. In this project, we are developing new tracers that combine the advantages of two complementary imaging techniques: spat
Protein-Ligand Useful Simulation for Fragment-Based Drug-Design – PLUS
One novel efficient approach for drug design is to use structural information such as the 3D structures of the proteins that will be the chosen therapeutic target. This approach is called Structure-based drug design and is useful for the optimisation of the interactions between the ligands (small or
Structure, Chemical Order and Reactivity of Gold-Palladium Nanoparticles: from vacuum to reaction conditions – AuPd-Seg
Because the extent to which segregation occurs can have implications for the performance and the lifetime of the catalyst, it is important to understand whether the particular configuration is stable under the operating environment for a specific application. For this purpose the present project aim
Rational design and synthesis of probes for chemical biology of the crypt-proteases – CHEM-CRYPTIDASES
Alzheimer’s disease is a devastating neurodegenerative disorder concerning about 20 million people. Among key features is the progressive accumulation of amyloid peptide deposits. leading to loss of neurons, cognitive deficit, and finally death. Understanding the mechanism of amyloid pathologically
Multifunctional molecular probes for fluorescence imaging of cell membranes – Cellmemprobes
Fluorescence bio-imaging is a rapidly expanding research area that opens possibilities for non-invasive detection of biomolecular targets with applications in both research and clinical diagnosis. This type of imaging requires specific tools, namely fluorescent probes. The general objective of the p
Design of a New Programmable and Dynamic Alternative Genetic System – PRODYGY
The approach developed in this project is to develop new alternative genetic systems, and will allow our team to develop interdisciplinary research programs at the international level in the fields of high technology and industrial applications. Achieving this goal will result in tremendous opportun
Use of Non-Innocent Ligands complexes as VERSatile ALternatives to noble metals – UNILVERSAL
Ongoing concerns in chemistry gravitate towards the reduction of waste presenting toxicity for the environment, and synthetic chemistry is often seen has the black sheep in this respect. Catalytic processes –which rely on the use of minute amounts of a molecule (catalyst) able to increase efficiency
Vinylfluorides by superacid mediated fluorination of heteroatom substituted alkynes – VINFLUSUP
The strategic use of fluorine substitution in drug design has culminated with now more than 25 % of drugs containing at least one fluorine atom. In this context, fluoroolefins clearly falls into the category of promising scaffolds both from chemical and pharmaceutical perspectives. They have been su
Gold-Catalyzed Heterocyclic Compounds Synthesis – Synt-Het-Au
In an international and dynamic competitiveness, gold catalysis allows to the development of new highly efficient synthesis tools. However, the high cost, the moderate stability and low turnover rates of current gold catalysts are clear limitations toward future industrial applications. To address
Heterosubstituted olefin tandem metathesis – total synthesis of lycorine type alkaloids. – Lycomet
Alkaloids belonging to the family of lycorines possess a tetracyclic scaffold based on the galanthane skeleton. These natural products differ in the stereochemistry of their ring junction as well as in their fonctionnalisation over the rings. A recent study has revealed that the lycorine as well as
Development of Smart Spin Probes – SonRadIs
Since decades, investigations of pathological and physiological events using spectroscopic techniques became more and more important. Nowadays, such events are investigated at the molecular level and require techniques exhibiting high levels of sensitivity, resolution and specificity of the bioproce