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Physical and functional plasticity of proteasomes. – PLASTIZOME
The proteasome system has become increasingly recognized as a controller of numerous physiological processes, including signal transduction, DNA repair, chromosome maintenance, transcriptional activation, cell cycle progression, cell survival, and certain immune cell functions. This is in addition t
Regulation of apoptosis and cell adhesion during development – RACADD
The aim of this research is to identify the signals that allow a cell to know that she must die as well as the influence of a dying cell to its environment. These studies are conducted on a model that allows the study of cell death during development, so in a tissue without artificial induction of c
Plastid/nucleus interactions during plant development – IPNODEV
Like animal cells, plant cells are divided in several compartments which function coordinately. The purpose of this project is to study interactions between the nucleus, which contains the genome, and chloroplasts which are plant-specific organelles and the site of photosynthesis, during plant devel
Dynamics of chromatin activation at the floral meristem – ChromFlow
Plant ontogeny is associated with highly flexible cell fates that allow organogenetic programs to take place throughout the plant lifespan. During organogenesis, small clusters of stem cells acquire new fates before differentiating into specific cell types. Such events are initiated by the activatio
CHromatin and ROS: Role of Topoisomerase VI-mediated chromatin remodelling in the transcriptional response of plants to singlet oxygen, ROS and abiotic stresses. – CHROS
The CHROS project is aimed at identifying the molecular mechanisms of the plant response to adverse environmental conditions, with particular emphasis on chromatin level control of gene expression in response to reactive oxygen species (ROS), as the production of ROS is a common feature of most abio
Characterization of the sister chromatid cohesion step of the E. coli cell cycle – SISTERS
The objectives of the SISTERS ANR project are to characterize the molecular factors controlling the sister chromatid cohesion step. The most striking features that was revealed by the SISTERS project was the fact that sister chromatid cohesion in bacteria is a two step process, controlled successive
Coordination between DNA synthesis, chromatin assembly and chromosomes segregation upon replication accidents. – Rep-Seg
The development of an individual from the state of a unique cell to grown-up stage requires billions of cellular divisions. During each division, a cell has to transmit an identical copy (qualitative aspect) and equal (quantitative aspect) of its set of chromosomes to its two daughter cells. For tha
Nuclear Organisation and dynamic of ribosomal constituents synthesis – ODyNRib
Despite growing evidence of a deterministic nuclear organization, the physiological consequence of spatial genome organization is still a subject of intense research. In budding yeast, using the invaluable genetic tools of this eukaryotic model, the kinetics of interaction of active genes with nucle
Molecular mechanisms underlying the coordination of cell growth and cell division – Growth and Division
Diverse cell types, from yeast to mammalian cells, often exhibit a dynamic pattern of growth throughout the cell cycle, dramatically changing cell polarity as cell cycle transitions occur. Communication between the cell cycle machinery and cytoskeletal components that organize the secretory apparatu
Protein scaffold and glycan clustering determine cellular uptake and physiological functions of glycosphingolipid binding lectins – GlycanClust
Each cell produces a distinct array of cell surface glycans that carries rich structural information unique to that cell. Multiple glycan-binding proteins called lectins have evolved to use glycans as receptors to mediate a vast variety of biological processes such as endocytosis, cellular trafficki
Chloroplast directed environmental stress acclimation in plants. – CHLORO_SAP
Chloroplasts are essential organelles that are the site of photosynthesis in green plants. By capturing and converting sun light photosynthesis is the primary source of chemical energy for the whole biosphere. Chloroplasts were formed when a eukaryotic cell swallowed an ancient cyanobacterium. Today