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Exposure to persistent organic pollutants and severity of endometriosis in the ComPaRe-Endometriosis cohort – POPENDO
Endometriosis is a chronic hormone-dependent disease affecting 10% of women. Endocrine-disruptors have been suspected to play a role in endometriosis etiology, and several persistent organic pollutants (POPs) have been associated with endometriosis risk. However, despite experimental evidence of an
are Organophosphate flame Retardants Affecting the NeuroDevelopment ? A Neuroimaging Investigation – ORANDANI
Organophosphate flame retardants (OPFRs) are emerging chemicals with high prevalence and controllable sources of exposure. Toxicological studies support their neurotoxicity, but epidemiological studies on their effects on child mental health are scarce and challenged by the below-mentioned features.
When adolescents face a relative’s illness/disability and become a carer: Longitudinal impact on quality of life and academic performance – ELIAS
Context: Adolescents may face the illness/disability of a relative. Those who provide a significant support are called young carers (YC). If some research has been undertaken in France about children facing a parent or a sibling illness/disability, the support they may provide is ignored. Thus, YC a
The authority of scientific medicine in the era of controversies over clinical research – AMES
Medicine continues its scientification. This is particularly the case in the field of clinical research, which crystallises this alliance between medicine and science. However, since the 1990s there has been an increase in the number of public controversies concerning health issues, particu
Response shift evaluation with continuous time Rasch models – RESCUE
Self-Reported Outcomes (SRO) such as anxiety or quality of life are frequently assessed with questionnaires to better understand the subjective experience of individuals and to inform healthcare decision-making. Faced with a major life event (e.g. COVID-19 crisis), people may change their perception
Integrating multiple sources of evidence for optimized comparative effectiveness research – OptiCER
The systematic identification and synthesis of all available evidence on a specific clinical question is an integral part of the medical decision-making process and the planning of future research. For most medical conditions, a plethora of healthcare interventions are available and, thus, network m
Cardiometabolic health outcomes and their association with Plant-based dietary pattern in the current nutritionally sustainable transition: an epidemiological multi-COhort study – CaPulCo
WHO has been estimated that healthy lifestyles, including sufficient physical activity level and a healthy diet, could decrease between 81 to 94% myocardial infarction risks worldwide. Food behaviors considered unhealthy regarding cardiovascular health mostly result from a first « occidental » nutri
Genomic innovation trajectories in care settings – TraGenInnov
Genomic technologies are a set of machines and associated devices, widespread in a variety of health care contexts, where their use has become massified and routinised. Social science studies have analysed the conditions of their introduction into specific clinical fields, but little attention has b
National Evaluation of MOuld contamination in French Dwellings – NEMoD
Indoor exposure to mould and dampness in dwellings are a risk factor for the development and/or evolution of several respiratory diseases (including asthma and rhinitis). Added to the negative effects on health, strong social inequalities are related to mould exposure. In order to design effective
Joint Modeling the number of Quality-Adjusted Life Years – JM-QALYs
The most effective clinical intervention in terms of survival may not necessarily be the best from the patient’s perspective if survival gain involves serious deterioration of Health-Related Quality of Life due to treatment side effects. The objective of the JM-QALYs project is to develop of patient
Efficient mobilization of COVID-19 Testing Resources – EMTR
France has been heavily affected by the SARS-CoV-2 epidemic. Such epidemics have unique features: many individuals are asymptomatic or have mild symptoms and the risks differ largely across individuals. This means that individuals differ in their willingness to participate in testing, conditional on
Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease: The Neuro-Moms CHD study – Neuro-Moms-CHD
Congenital heart disease (CHD) is the leading cause of congenital malformations, representing 1% of live births. Progress in surgical care have led to the dramatic increase in the population of children and adults living with heart disease. As survival is no longer a concern, long-term outcomes have
Influence of gender norms on epigenetic markers of health – EpiGender
Male dominance is almost universal across human populations, so gender norms tend to favour men as compared to women: women exhibit lower access to resources, lower autonomy, lower social support and receive lower parental investment. In this project, we aim at evaluating the influence of such male-
Primary care facing the COVID-19 pandemic in Cuba: Spatial differences, social vulnerabilities, experiences, and lessons at a global lLevel – PrimaCoba
Primary healthcare (PHC) in Cuba are considered as a model, notably by the WHO. During the COVID-19 pandemic, PHC have played a key role in health policies in Cuba. While the country was largely preserved from the pandemic until early 2021, a severe epidemic episode occurred between June and August
"Words Fail Me": Naming the Unnamable – PERINAT
The suffering that a family struck by perinatal grief has to endure is exacerbated by the silence and ensuing isolation from peers that surrounds this event, widely associated to stigma and taboo in Western societies, so much so that perinatal death is also referred to as the “silent” or “invisible”
Adapted physical activity as complementary treatment to alleviate the symptoms of endometriosis? The CRESCENDO program (inCRease physical Exercise and Sport to Combat ENDOmetriosis) – CRESCENDO
Recently, the French government reaffirmed its desire to better understand and fight against endometriosis via the national strategy against endometriosis (2022-2025), on the one hand, and its desire to actively participate in the promotion of physical activity and the reduction of sedentary behavio
Impact of sugar and periodontal disease on cognition: epidemiological and experimental study – DENTALCOG
In aging societies, identifying new ways to preserve cognitive health has become a major concern. In this context, the study of the oral cavity and periodontal disease is of growing interest. Periodontal disease, the most severe form of which is periodontitis, is a dysbiotic chronic inflammatory dis
Health determinants of people who are Lesbian, Gay, Bisexual, Transgender and other – Hope-LGBT
LGBT+ identity involves periods of negotiation with self, family and society. This can lead to crisis that can be detrimental to the health of LGBT+ people. Two periods are particularly critical: the disclosure of one's sexual orientation and the access to parenthood. At the same time, these two per