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Urinary peptidomic patterns of Long-COVID syndrome – UriCoV
Long COVID is the most frequent, yet poorly characterized sequelae of the world´s most impactful pandemic during the last 100 years. It has tremendous, yet not even foreseeable consequences on personal health and socioeconomic status of affected individuals and families, and on global macro-economi
PersonAlisation of RelApse risk in autoimmune DISEase – PARADISE
Autoimmune disease affects 10% of adults, most of whom are women, and two of the top five medications with the highest cost globally are used to maintain these recurring conditions in remission. These medications act by suppressing the immune system, leaving the patient exposed to severe infection a
Urine biomarkers for bladder cancer initial detection and surveillance: a multicentric study to assess the diagnostic accuracy of a comprehensive tool. – UBIOBCA
Bladder cancer (BC) ranks as the tenth most prevalent cancer in the world (IARC, WHO), with a steady rise in its incidence and prevalence, and is accompanied by a high morbidity and mortality. Absence of reliable screening methods, invasiveness of diagnostic modalities, and high recurrence rates, ma
Digital Twins to Treat Atrial Fibrillation – DAWN-AF
Atrial Fibrillation (AF) is the most common cardiac arrhythmia, with incidence increasing with age: 10% of the population > 80 years is afflicted with it. As AF is progressive, over time it is harder to treat, which increases risk of stroke, dementia and heart failure. The most effective treatment i
MEDICAL COMORBIDITIES IN BIPOLAR DISORDER: CLINICAL VALIDATION OF RISK FACTORS AND BIOMARKERS TO IMPROVE PREVENTION AND TREATMENT (BIPCOM) – BIPCOM
Bipolar Disorder (BD) is a common, heritable, chronic, and recurrent disorder that represents a critical public health problem, due to its prevalence, its high degree of disability and psychiatric and medical comorbidities (MC): these represent a significant additive burden for BD patients, with a l
Towards a personalized medicine approach to psychological treatment for psychosis – PERMEPSY
Despite the importance of psychological interventions in people with psychosis, fewer patients receive them and there are no studies aiming to characterise patient phenotype in relation to patient response. This project poses the challenge of integrating new technologies (harmonization, Machine Lear
Personalising myasthenia gravis medicine: from “one-fits-all” to patient-specific immunosuppression – MG-PerMed
Myasthenia Gravis (MG) is a prototypic autoimmune disease causing muscle weakness and fatigability, mostly treated by chronic immunosuppressive (IS) therapy. MG clinical heterogeneity, fluctuating symptoms with unpredictable disease course, and inter-individual variation in response to treatments, i
An integrated multi-omics signature of kidney fibrosis for CKD precision medicine – KidneySign
Affecting around 10% of the population, chronic kidney disease (CKD) is a concerning disease of European societies, which ultimate stage (end-stage kidney disease (ESKD)) is irreversible and fatal if untreated. The progression rate of CKD cannot be precisely assessed from estimated glomerular filtra
Prodromal DEtErminants for PhENoconversion of idiopathic RBD to alpha-synucleinopathies (PD, DLB and MSA) – DEEPEN-iRBD
Problem: Increasing evidence shows that individuals affected by idiopathic REM sleep behavior disorder (iRBD) have a high risk of conversion to Parkinson’s disease (PD), dementia with Lewy bodies (DLB) or multiple system atrophy (MSA), conditions that have a common cellular pathological hallmark, th
A multi-omic stratification and a non invasive tool for early recognition of triple negative and Her2+ breast cancer patients responders to neoadjuvant therapy – PORTRAIT
Neoadjuvant therapy (NAT) is the standard initial treatment for Triple Negative (TN) and Her2+ Breast cancer. Despite the similar clinical presentation, the tumor response to NAT diverges widely due to the influence of several individual factors - including microbiota - which have a crucial role in
Optimizing omega-3 supplementation to resolve inflammation in a personalized medicine cardiovascular disease prevention. – OmegaPerMed
Cardiovascular diseases (CVD) are the most common cause of death in Europe and world-wide. Optimizing CVD prevention is therefore of utmost importance, but personalized medicine has not yet reached clinical practice for CVD. Omega-3 polyunsaturated fatty acids (PUFA) are traditionally considered ben
MULTI-MARKERS RISK ASSESSMENT OF KIDNEY SENSITIVITY TO INJURY TO PERSONALIZE PREVENTION OF ACUTE KIDNEY INJURY – SPAREKID
Acute kidney injury (AKI) is a life-threatening disease with high mortality characterized by an abrupt decrease of the kidney glomerular filtration rate, extra-kidney consequences (cardiovascular diseases, lung injury, neurological impairment) and high risk of secondary chronic kidney disease. The
Patient Stratification by Standardization of the Image-based Sweat Test for Cystic Fibrosis for use in Clinical Routine – Stracyfic
The demonstration of a salty sweat has long been used to diagnose cystic fibrosis (CF), a rare disorder affecting 1 in 2,500 live births and associated with high morbidity and mortality. CF represents the most frequent recessive genetic disorder. CF is caused by CFTR mutations resulting in loss-o
Body fluid proteome SIGnatures for persoNALised intervention to prevent cardiovascular and renal complications in diabetes – SIGNAL
Diabetes and the associated cardiovascular and renal complications are among the largest burdens for patients, and also the public healthcare system. In Europe 700.000 deaths are attributed to diabetes and associated complications yearly, with costs exceeding 200 bn €. Diabetic kidney disease reduce