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Tools for functional rehabilitation of the upper limb for children with cerebral palsy and related disorders – CPlay
The CPlay project aims to develop functional rehabilitation tools for the upper limb of children affected by cerebral palsy. The proposed solution combines the use of 1) instrumented objects from the daily life of the child and 2) mixed reality techniques. These rehabilitation tools can be used both
Sensors and monitoring instruments in Equine E-Health: Application to the prevention and management of locomotor disorders by optimizing training and sport rehabilitation. – CAPT-ESE
The objective of the CAPT-ESE project is the development of embedded sensors specific to the equine athlete and his rider, tools to assist training management in the prevention, early diagnosis and treatment of locomotor disorders. Around a consortium bringing together biomechanical researchers,
Dévelopment of a Polydopamine Hybridized Iron Oxide Mussel Inspired Cluster for molecular MRI – pHySIOMIC
Despite significant progress in prevention and acute care over the past decades, ischemic stroke prevalence is on the rise with population aging and is expected to affect 1.3 million people per year in Europe by 2025.1 While the rapid management of strokes saves the lives of half of the patients, th
Unmasking Thrombo-inflammation by in vivo Molecular Magnetic Resonance Imaging of von Willebrand Factor – FlaMRIng
Thrombo-inflammation has emerged as a key pathophysiologic player in a large number of disorders. It is caused by the activation of endothelial cells in injured tissues, leading to secondary microvascular thrombosis and further tissue damage. To date, available imaging methods only allow to detect t
Magnetic Resonance Fingerprinting Unification for Stroke Emergencies – MRFUSE
The general aim of MR FUSE is the development of new Magnetic Resonance (MR) imaging tools for the management of acute stroke patients. We propose to use the concept of MR ‘fingerprinting’ combined with artificial intelligence algorithms to create fast (
Biomimetic collagen tubular constructs for vascular and tracheal grafting – MIMETUBE
MIMETUBE aims at providing new types of tubular biomaterials to address unmet clinical needs in vascular and thoracic surgery, and to serve as platforms for fundamental investigations of graft integration and tissue regeneration. The consortium gathers materials scientists, physicists, physiologists
Fast and non-invasive multi-mode fiber imaging – NAIMA
Microscopic imaging methods have become essential tools for biomedical research at the cellular level. In particular, the optical sectioning capability of the two-photon microscope together with the development of genetically encoded activity sensors have driven a wide range of discoveries about ner
Very Low field MRI for babies – VLFMRI
VLFMRI aims at developing a very low-field Magnetic Resonance Imaging (MRI) system as an alternative to conventional high-field MRI for continuous imaging of premature newborns to detect haemorrhages or ischemia. This system is based on a combination of a new generation of magnetic sensors based on
PERMANENT MONITORING OF THE CEREBRAL BLOOD VOLUME IN THE BRAIN INJURED PATIENT TOWARD IMPLANTABLE ULTRASENSITIVE DOPPLER: THE BRAINCAM. – BrainCam
Brain damage resulting from traumatic brain injury or subarachnoid hemorrhage is a major cause of death and severe disability. A significant contribution to the morbidity arises from secondary brain ischemic damage. The cornerstone of neurocritical care management is optimization of cerebral blood f
Astrocyte preservation after cardiac arrest treated by hypothermic liquid ventilation – ASTRAL
Cardiac arrest is a major health issue with very low survival rate. In order to improve the neurological prognosis and the survival rate of resuscitated patients, the laboratory is developing a breakthrough technology for the induction of ultra-rapid hypothermia after cardiac arrest by hypothermic T
Fiber-based In-vivo Realtime Dosimetry for Pulsed Radiotherapy – FIDELIO
State-of-the-art real-time dosimeters used for quality assurance or in-vivo dosimetry (IVD) measurements in radiotherapy (RT) have become ill-adapted to modern treatment practices which use highly conformational and stereotactic irradiations, or ‘pencil-beam scanning’ irradiations in the case of hig
SPARse array TECHniques FOR 3D medical UltraSound – SPARTECHUS
SPARTECHUS is a collaborative research project between the Ultrasound Imaging team of CREATIS, a medical imaging research center, and Imasonic, a manufacturer of ultrasound transducers. Its objective is to develop a new technology of single-element transducers and combine them optimally to produce h
Medication Review Support – ABiMed
Polypharmacy is a major public health problem. It causes adverse events and drug-drug interactions, but it also has an important cost for health insurances. A solution is the medication review: a pharmacist interviews the patient, reviews his medications and simplify the treatment, by removing non-m
Selective extraction of metals from the brain for Parkinson’s disease – SEMB
The objective of the SEMB project is to propose (i) new strategies based on innovative chelating hybrid materials, (ii) diagnostic methods using metal ions as biomarkers and (iii) treatments for neurodegenerative diseases correlated to dysregulation of metallic homeostasis. The project will focus on
Development of a Bio Medical Device (MD) for the prevention of the risk of pharyngeal fistula following total (pharyngo) laryngectomy – BIOFISS
This project aims to develop a specific biomaterial for the prevention of the occurrence of SF in accordance with the specifications established with the Surgery team and industrial expertise. Relying on previous works (Conzatti 2019), this innovative biomaterial will be used as a medical device (MD
Development of new composite scaffolds by freeze-casting for the treatment of the mandibular osteoradionecrosis – CongOs
The CongOs project aims to develop a new porous composite material with antibacterial and angiogenic properties for bone reconstruction following mandibular osteoradionecrosis (MRO) with a defect size > 1cm2. These materials are composite scaffolds based on nanoscopic aliphatic polyester/bioactive g
From novel rehabilitation protocols to visual aid systems for low vision people through Virtual Reality – DEVISE
Context: More than one million persons in France are blind in the central part of their visual field because of a non-curable retinopathy (mainly Age related Macular Degeneration - AMD). This central field loss induces dramatic deficits in several high-level perceptual abilities: mainly text reading
A soft glue to close wounds and relieve pain – SoftGlue
Pain is one of the most distressing symptoms during the early postoperative period. Pain also occurs when rigid sealants are employed to stick tissues or close wounds as they hurt fragile tissues. To the best of our knowledge there is yet no sealant able to connect tissues in a soft manner. In this
Active Wireless Wound Dressings integrating Graphene for wound Healing Monitoring and Infection Detection – PADISC
The market of “smart dressing” is still in its infancy, but is expected to rise quickly following the trend of personalized regenerative medicine, connected wearables and embedded devices for remote patient monitoring. The main objective of PADISC project is to seize this market trend by taking
Laser-assisted fabrication of silicone-based patches for transdermal drug release – Labricon
Silicone-based transdermal drug delivery patches are currently used in a wide range of pharmaceutical applications from hormone therapy to central nervous system related pathologies. However, their manufacture has relatively high technology barrier, impacting their price and limiting their utilizati
Droplet-based Textile Microfluidics for High-Throughput Organoids Screening – DROMOS
The project aims to develop a new type of platform for screening from cellular spheroids. This platform is based on the microfluidic technology of drops, or more precisely of «plugs«, i.e. drops strongly confined in a cylindrical channel. Each channel contains a «train« with several series of drops
New approach for type 2 diabetes early diagnosis – ASCFinder
Type 2 diabetes (T2D) is one of the most prevalent chronic diseases in the world, and it increases alongside the growing prevalence of obesity and aging. Detection of T2D is often delayed and used biomarkers have limitations since they are detected when the disease is established. We very recently d
Label-Free Multiparametric Biomedical Imaging Based on the Photonic Crystal Surface Waves – FreeBioWave
The possibility of highly sensitive multiparametric detection and recognition of target biomarkers complemented by kinetic data of their interaction obtained in real time without labeling is a paradigm of modern in vitro diagnostics. Nowadays, label-free optical sensors employing surface plasmon res
Regenerative Endodontic via a tannic acid functionalized electrospun cone – RooTRaCE
Pulp pathologies generated by infectious diseases or by trauma have an impact on the maintenance of the integrity of the dental organ and thus its function in the long term. Indeed, the treatment of these pathologies is still based on care techniques, root canal treatments, which do not allow the he
A first-of-its-kind functional connectivity neuroimager for early diagnosis of neonatal abnormal cerebral development – ConexUS
Neurodevelopmental disorders result from an impaired brain development and represent a major public health problem affecting 1 million newborns in Europe each year. Neurodevelopmental disorders are the source of permanent disabilities that manifest as motor, cognitive, learning or behavioral dysfunc
Temporal diffusion spectroscopy in nonalcoholic steatohepatitis – STEDI-NASH
Nonalcoolic steatohepatitis causes an increasing number of hepatic cancers. It is characterized by hepatic steatosis, inflammation and hepatocyte ballooning, and can be associated with fibrosis. Some imaging methods can be used to diagnose steatosis, fibrosis or inflammation, but none is available f
A novel quantitative magnetic resonance imaging protocol for comprehensive evaluation of skeletal muscle tissue structure in muscular dystrophy – MR-MyoMap
During the past decades, MRI has become a key modality for diagnosing soft tissue diseases. Particularly in the field of muscular dystrophies (MD), MRI has developed into a valuable complementary diagnostic tool that allows assessment of the degree and, more importantly, the pattern of muscle involv
MUSCOVADO: MUlticale SCaffOld-free and VAsculariseD Organoid-based tissue: fabrication & comprehension – MUSCOVADO
Regenerative medicine is a burning stake for public health. The growing expectations for tissues that are engineered from patient’s cells and no longer from donors is a major challenge. Although culturing small pieces of tissues in vitro is nowadays mastered, scaling up the process in terms of tissu
An osteoconductive and nutritive foam to promote survival and functionality of osteocompetent cells transplanted into large bone defects – STARCHBONE
This project aims to develop an alternative to autologous bone grafting. It is based on a paradigm shift: glucose (not oxygen) is necessary for the survival and paracrine functions of mesenchymal stem cells (MSCs) in vivo. It is based on preliminary results demonstrating that a material combining st
Non-invasive cardiac work assessment using stiffness-strain loops validated against PET imaging and invasive pressure-volume loops – CARDIOLOOP
Heart failure (HF) is associated with a high risk of death the first year after diagnosis. Echocardiography is commonly used to diagnose HF. However, there is currently no method available in the clinic to early detect systolic or diastolic HF before apparitions of acute symptoms. In both cases, the
Images and models for Video-Assisted Thoracic Surgery (VATS) – VATSop
The project deals about augmented reality assistance for the localization of pulmonary nodules during Video-assisted thoracoscopic surgery (VATS). In order to avoid preoperative invasive localization procedures, we propose to guide the VATS using only Cone Beam Computed Tomography (CBCT) intraoperat
Advanced chelators for innovative diagnosis technologies – ACHETE
In order to ensure the follow-up of a cancer patient, from the diagnosis and throughout the (post)treatment process, anatomical imagery is no longer sufficient and needs to be associated to single-cell analysis techniques to better understand the characteristics of cancer cells. Among the imaging m
Lens-based ultrasonic transcranial deep brain stimulation – ULTRASTIM
Neuromodulation (the alteration of nerve activity) plays a major role in the treatment of neurological diseases. A number of techniques that either improve accuracy (Deep Brain Stimulation), or offer non-invasiveness (Transcranial Electric Stimulation (TES), Transcranial Magnetic Stimulation (TMS))