Search
Therapeutic targeting and chemical biology of histone chaperones using rationally designed medium-size inhibitors – THERA-HCi
The histone chaperone ASF1 plays a crucial role in maintaining epigenetic information. The overexpression of the ASF1B isoform induces the proliferation of tumor cells and constitutes an excellent marker of poor prognosis for breast cancer. ASF1 is also implicated in aging and is involved in the liv
NEW ANGIOGENIC AND OSTEOGENIC PULLULAN-DEXTRAN PRODUCTS FOR SEGMENTAL BONE DEFECT TREATMENT IN ORTHOPEDIC AND ORAL SURGERY. – GlycoMb
The treatment of segmental bone lesions is a challenge for orthopedic and maxillofacial surgeons who use therapeutic solutions that cause morbidity and high costs for society. Based on the results obtained from an existing partnership which result to a patent and the creation of the company SilTi
Preclinical development of an innovative non-viral gene therapy for treatment of retinal degeneration – RetinaCARE
Retinal degenerative diseases such as dry age-related macular degeneration (AMD) or retinitis pigmentosa (RP) are the leading cause of human blindness worldwide with still no treatment option. These diseases are characterized by the irreversible loss of the retinal cells responsible for vision, the
MItochondria to boost MEsenchymal stem cells TherapeutIc capacities for Cardiac ischemia. – MiMeTiC
Repairing damaged hearts following an ischemic insult, such as myocardial infarction (MI), remains a major challenge in regenerative medicine. In this regard, mesenchymal stem cells (MSCs) represent a promising approach to repair damaged hearts since MSCs were shown to be safe and their use feasible
Optogenetic engineering of stem cell-derived photoreceptors to improve visual restoration in non-human primates – OPTOSTEM
Due to the recognition of the unmet need to treat retinal degenerative diseases, strategies to develop cell therapies aiming at replacing degenerated cells are receiving considerable attention. Although the approach based on transplantation of photoreceptors holds great promise, thus far, limited fu
Zebrafish for exploring Exosome-like Nanovesicle THerapeutic potential – ZENiTh
Extracellular vesicles (EVs) like exosomes generate high expectations from the biomedical world as to their future use as non-invasive diagnostic and prognostic biomarkers and natural therapeutic vectors as illustrated by the numerous EV-based biotechs founded and by an expected global EV market siz
Resorbable Polyhydroxyurethane (PHU) adhesives for the prevention of seroma complications and the promotion of optimal wound healing, after oncologic breast surgeries – Greenglue
After reconstructive surgeries such as oncologic breast surgeries, the most common early complication is seroma (i.e. local accumulation of fluids) in 15-40% patients. The medico-social burden is high, e.g. ˜500 mios€/year worldwide for breast surgeries. Suturing techniques or fibrin glue have been
Drug-design based on light controlled NO release nitrosyl ruthenium complexes: Antibacterial and wound healing agents – NOBacLight
Task 1 computationally designs, synthetizes and characterizes the NO photo-release properties of a library of Ru-NO complexes. Task 2 is dedicated to the biological screening of these compounds in order to select the two ones presenting efficient antimicrobial properties together with low to ine
Engineering antibacterial cationic amphipathic peptidomimetics for targeting biofilm-embedded and intracellular bacteria – AmphiPep
Critical challenges remain in the battle against infectious diseases. The emergence of antimicrobial resistances is not the unique serious threat for patients. Infections associated with bacterial specific lifestyles such as sanctuarization in biofilm or inside cells, are also difficult-to-treat wit
Targeted treatment of thrombotic diseases – FightClot
The overall objective of FightClot is to establish a new paradigm based on theranostic microbubbles to enhance the thrombolysis while ensuring the safety of patients. First, we will use an original double mutant of alteplase without neurotoxic side effects. Second, we will elaborate cytocompatible e
Therapeutic potential of neuropeptide FF receptor antagonists in the modulation of opioid analgesia and chronic pain – PAINFF
Chronic pain is a major health problem and a socio-economical burden. Despite sustained research efforts and the increasing diversity of available therapeutic approaches, most medications fall short in alleviating chronic pain syndromes. As a matter of fact, opiates and their derivatives, which targ
DEciphering The mOde of action of powerful New AntiTuberculOsis dRugs – DETONATOR
The emergence of antimicrobial resistance among tuberculosis (TB) harshly impairs TB control. Fluoroquinolones (TB) are one of the core antibiotics used to treat MDR-TB. Analysis of structure activity relationship among a series of lipophilic analogues of FQ recently synthesized revealed 2 molecules
CRX gene therapy in mouse and human models of retinal dystrophies targeting dominant CRX-associated retinopathies – CuRAT
Inherited retinal dystrophies (IRDs) are genetically and clinically heterogeneous. Despite tremendous progress in IRD research over the past 10 years, these diseases still lead to legal blindness due to limited therapeutic options. The recent success of gene supplementation therapy in patients with
Identification of novel Host-Targeted Antimicrobial therapies for mixed Respiratory Infections – Ho-TARI
Acute respiratory infections (ARI), remain one of the most important causes of death in both adults and children worldwide. The etiological agents of these infections are mainly viruses, such as influenza viruses, respiratory syncytial virus, or opportunistic bacteria such as S. pneumoniae or S. aur
Advanced glomerular capillary wall on chip system – AWACS
The increase of the kidney diseases prevalence is a worldwide major public health issue due to the high cost of treatments at the end-stage kidney failure (dialysis or transplantation). It is so needed to better understand kidney physiological and physiopathological mechanisms, particularly those of
Methodological development to accelerate identification & optimization of covalent hits – Cov-H2L
The objective of the 'Cov-H2L' project is to develop a robust method for the rapid identification of functionalizable fragments with a covalent mode of action, which can be optimized into lead compounds. To achieve this objective, a library of standard electrophiles will be generated, using commerci
PAR1 antagonist and companion assay for Crohn’s disease: A pre-clinical study – PARCURE
The general objective of the project is to propose the development of a novel product for the treatment of Crohn’s disease, with the potential to address unmet medical needs. With the present project, we aim at establishing the best pre-clinical conditions, in order to start soon after, Phase-II Cli
STROKE THROMBOLYSIS WITH r-tPA IMPROVED BY CERIUM OXIDE NANOPARTICLES – STRIC-ON
Ischemic stroke results from the thrombotic obstruction of cervical or cerebral arteries leading to cerebral infarction with neurological dysfunction, and represents the second cause of mortality and the first cause of acquired disability in France and Europe. The primary goal of stroke treatment is
Intramolecular DEep Expertise Diagnostic by Isotope Ratio Mass Spectrometry – INDEED-IRMS
Developing new methods of early diagnosis, prognosis and therapeutic strategies relies heavily on biomarker discovery. Based on our first patented results, we intend to set up and exploit new isotopic mass spec (IRMS) techniques to access Position-Specific Isotopic Analysis (PSIA). That is, we will
Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites – EpiKillMal
Malaria is caused by the infection with parasites belonging to the genus Plasmodium. Malaria remains a major global health problem due to the increasing spread of drug resistance and more than 400,000 deaths per year. New drugs that target multidrug resistant parasites are of highest priority. The u
Donor-specific regulatory T cell therapy through genetic engineering – DAISY
In solid organ transplantation, immune incompatibility between donor and recipient leads to a vigorous immune response against the graft, entailing rejection in absence of treatment. Prevention of graft rejection requires long-term administration of immunosuppressive drugs that dampen all immune res
ERAP inhibitors as a new approach to treat autoimmune & autoinflammatory diseases – ERAPIMM
ERAP enzymes that trim peptides into mature epitopes for their presentation to the immune system by MHC class-I, have been associated with the risk of developing autoimmune and autoinflammatory diseases such as the rare Behçet’s disease and ankylosing spondylarthritis, for which no satisfactory trea
A new technology for rapid antimicrobial susceptibility testing – DAMOCLES
Increase of antimicrobial resistance is a major public health problem. This problem, which mainly concerns Gram-negative bacteria (GNB), occurs in humans as well as in animals and in the environment. Faced with this overall increase in antibiotic resistance levels, the clinician who suspects a bacte
EXtracellular matrix in CArdiac disease: poLYsaccharides to reBUild the heaRt – EXCALYBUR
Heart ischemia (HI) has remained the world's leading cause of death for the past 20 years. Following hypoxia, the heart undergoes several changes developing a chronic disease: heart failure. In recent years, alternative therapies based on tissue engineering have addressed the fundamental problem of
Molecular Imaging of AtheroThrombosis – MIAT
With 17.6 million of individuals / year, cardiovascular diseases represent the first cause of death in the world, the majority of those deaths being attributed to coronary artery disease (CAD). The underlying mechanism of CAD is the development of atherosclerotic plaques within the wall of coronary
Heart-targeting agents for therapeutic delivery in failing cardiomyocytes – CardioTarget
Heart failure (HF) is one of the main cardiovascular diseases and is defined as the inability of the heart to meet the body’s circulatory demand. HF constitutes a major health problem, affecting about 1-2% of the adult industrialized-countries population. In spite of huge progress in its treatment o
Structure and function of the cellular target of the anti-Shiga toxin drug candidate Retro-2.1 – SMERSEC
The new chemical entity Retro-2 has a remarkable capacity to protect cells and mice from Shiga-like toxins, ricin, and a number of viruses, without toxicity. The optimized analogue Retro-2.1 is being developed as a drug candidate to prevent the hemolytic and uremic syndrome, a deadly complication of
Osteocytes extracellular vesicles cargos: a new approach for regenerative medicine of bone tissue – OVERbone
There are increasing clinical situations in which bone regeneration is required for skeletal reconstruction of large bone defects. A therapeutic issue is to restore bone mass by stimulating osteogenic activity. OVERbone aims to investigate a novel mechanism of bone formation based on extracellular v
Encapsulation of metabolically standardized MSC as a novel osteoarthritis therapy – METAB-OA
Osteoarthritis (OA), the most prevalent joint disease, is characterized by structural and functional alterations of all joint components. The most promising cell-based therapy approach for OA relies on the use of pleiotropic mesenchymal stromal/stem cells (MSC) that display tissue-protective and imm
Targeting a Plasmodium propeller domain protein to prevent malaria liver stage infection – MALPROP
Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial and obligatory round of replication, before initiating the symptomatic blood stages. Infection of the liver is clinically silent and constitutes an ideal target for a malaria vaccine
Development of RNA aptamers targeting the NADPH oxidase DUOX1 as a therapeutic approach to treat lung fibrosis – APFIBROX
Chronic respiratory diseases, including lung fibrosis are a major and increasing burden in terms of morbidity and mortality. Lung fibrosis is characterized by excessive matrix deposition leading to destruction of lung architecture and ultimately fatal impairment of lung function. Idiopathic pulmonar
Nanobodies targeting mGlu receptors as innovative agents for schizophrenia – Nano4Schizo
Schizophrenia (SCZ) affects more than 1% of the population, and has strong impact on the social life of patients. It is increasingly recognized as a neuro-developmental disorder with an early onset in young adults, often between 20-30 years of age. Currently available treatments mainly target the do
Design, synthesis and nanovectorization of pleiotropic prodrugs, with potential therapeutic interest in Down syndrome and Alzheimer’s disease. – DOWNALZ
This project aims at designing novel pleiotropic prodrugs, under a mucoadhesive liposomal formulation for intranasal administration, with potential therapeutic interest in Down Syndrome (DS) and Alzheimer's disease (AD). The prodrugs will be activated through the covalent inhibition of butyrylcholin
Novel Pickering Emulsions for Inflammatory Dermatoses – NoEmID
Inflammatory dermatoses include two multifactorial pathologies, psoriasis and atopic dermatitis, with a very high global prevalence in the world. Current treatments, topical or systemic, are often partially effective as targeting only one component of the disease (either immune system or epidermal i
Dynamic IMaging of IMmune system interaction with glioblastoma boosted by Focus Ultrasons Strategy to improve personalized therapy – IM2FUS
The brain is by far our most precious organ. That is why the brain is the best-protected organ in the body. The key protective element in our brain system is the blood-brain barrier (BBB) that protect our brain against disease-causing pathogens and toxins that may be present in our blood. However, t
Extracellular vesicles as secondary messengers for virus-delivered therapeutics – EXOVIR
Systemic therapeutic targeting of molecules located within specific cells is a major issue for numerous fields of health research. This targeting requires the development of innovative vectorization strategies to guarantee both the efficacy and the safety of treatments. Using as a model the targetin
Disrupting TRIP8b-HCN interaction: Toward an innovative and well tolerated therapeutic strategy against neuropathic pain – PHARMHCN
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse side effect of anticancer agents that seriously compromises the patient’s quality of life, limits dosage, and leads to changes in treatment to non-neurotoxic agents with the risk of limiting the effective clinical outcome. Among
Restoration of a functional spermatogenesis in infertile mice by in vivo therapy. – SPERMREPAIR
Infertility affects 1 in 7 couples and has become a public health concern. In 50% of cases, it is of male origin and is mainly due to abnormalities in spermatogenesis leading to defects in sperm production. One of the most severe sperm abnormalities is non-obstructive azoospermia (NOA), defined by i
Nanotherapy to modulate the immune response in sepsis – NANOSEPSIS
Sepsis is a leading global cause of death that is linked to the dysregulated systemic inflammatory response to an infection. The innate immune response to foreign bacterial molecules typically induces the activation of circulating monocytes and the production of pro-inflammatory cytokines. This sign