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Innovation designed to evaluate and improve heart graft quality before transplantation – LIFEGRAFT
The project leader invented a new device for hypothermic pulsed perfusion, named INOVAGRAFT (2 patents, Inserm Prize 2015 for Innovation), which would drastically enhance the duration of grafts transport. Associated with a new carrier of O2 derived from marine worms (HEMO2life®, patented by the comp
High-throughput droplet-based analysis of influenza A virus reassortment by single-virus RNA sequencing, for pandemic risk assessment and Candidate Vaccine Viruses optimisation – microFLU-REASSORT
The objective of microFlu-REASSORT is to implement an innovative droplet-based microfluidic approach in order to quantify experimentally and in a statistically robust manner the result of genetic reassortment between two strains of IAV. To achieve this ambitious goal, the Naffakh and Griffiths gr
Development of a novel oral drug delivery platform based on Hydrogel-Doped Nanoparticles – HyDNano
HyDNano aims at developing an original hybrid system made of nanomedicine loaded into an hydrogel matrix to control local or systemic drug delivery following oral administration. This strategy represents an innovative and unique approach for achieving a controlled release of actives, via oral route,
COntroLling Tolerance through CD45RC – COLT-45RC
GVHD is among the major causes of mortality following bone marrow transplantation. Therapy with ex vivo expanded CD4+Tregs was shown to efficiently prevent GVHD in murine models and phase I/II clinical trials have shown encouraging results. Nevertheless, the growth of Tregs is costly and long. An al
Water-soluble aza-BODIPY platform for multimodal imaging and trackable therapeutics – WazaBY
Among the different disciplines in medical imaging, molecular imaging is an emerging powerful tool, which enables to detect pathophysiological changes in living subject at the cellular and molecular level. More particularly, optical imaging (OI) is the method of choice for in vitro and ex vivo studi
Topical dermal delivery of anti-inflammatory drugs with catanionic vesicles for the treatment of psoriasis – TANDANSS
The TANDANSS project proposes an innovative and competitive positioning that could bring about decisive advances to extend the knowledge related to acute health and wellness societal issues related to chronic skin inflammatory diseases, and in particular psoriasis. The TANDANSS project will take u
Enhancing the therapeutic effect of MSC in osteoarthritis: role of PPARb/d – PPAROA
Osteoarthritis (OA) is the most common degenerative and inflammatory joint disorder. Despite the increase in OA incidence, there is still no effective treatment capable of restoring the structure of articular cartilage and function of damaged joints. Consequently, mesenchymal stromal/stem cell (MSC)
Manganese complexes for PET and MRI: production of 52Mn and ligand design for stable and inert complexation – MANGA
The proposal has a double objective : to explore bispidine-type ligands for Mn complexation and to produce the Mn-52 isotope for the first time in France, in the cyclotron of Orléans. A Mn complex with unprecedented kinetic inertness has been identified. Mn-52 has been produced in France for the fi
Developing BET proteins inhibitors as a novel class of antifungal drugs – InhiBET
Our preliminary and recently published data reveal the translational potential of Bdf1 bromodomain inhibition as a novel therapeutic strategy to treat systemic Candida infections. The identification of inhibitors which are not only active against Bdf1 in biochemical assays but also cytotoxic towards
Syncytins for genome engineering in B cells – SYN-B
The main objective of the SYN-B project is to engineer the genes of immunoglobulins in B lymphocytes in order to re-program the antigenic specificity of cells («induced Ag-specificity replacement« (iASR)) or to modify the heavy chain class of antibodies produced by cells (induced class switch recomb
FLT3 inhibitors for the treatment of neuropathic pain – NEUROPATH
The challenge is to design and develop an effective and well-tolerated molecule for the treatment of NP. As it is a chronic disease, which requires long-term treatments, the issue of drug safety is essential. «Classic« Tyrosine Kinase Receptor (RTK) inhibitors target intracellular kinase, the struct
Trypsin-3 Inhibition Therapy And Novelty – TITAN
In this Biomedical Innovation grant, we hypothesized that we could identify lead compounds for drug development for the treatment of IBS, based on the inhibition of Trypsin-3, and we propose: - to establish assays that would allow the screening for specific Trypsin-3 inhibitors from libraries of m
Identification of Small Molecules Aborting Resistance to TB prodrugs – SMARt-TB
Using an innovative screening approach, we have identified Small-Molecules Aborting Resistance (SMARt) to the two nitroimidazoles prodrugs: pretomanid and delamanid. The first goals of this project is to unravel the mode of action of these compounds. The second goal will be to study the proteins t
Engineered 3D brown-like adipocytes derived from human iPSCs for in vitro preclinical drug discovery and for cell-based therapy to treat obesity – hiPSC-Adipospheres
Studies on browning of white adipose tissue are limited by the lack of in vitro models mimicking physiological conditions and the native microenvironment. The models conventionally used are mono-cultures, cultured in 2 dimensions (2D), experimental conditions relatively far from the physiological co
Nacre, a source of new drug candidates for osteoporosis – NADO
Research hypothese: Nacre is not only a source of calcium but also a source of bioactive compounds on both bone anabolism and resorption, i.e. bone remodeling. Thus, we propose simultaneous preventive and therapeutic approaches by correcting calcium deficiency and modulating bone cellular activitie
Physio-mechanical investigation of a synthetic elastic protein as a molecular prothesis to heal arteriopathies related to elastic fibre defects – Arterylastic
Arterylastic project aims at restoring the function and mechanical properties of blood vessels using an original synthetic elastic protein recently developed by the principal investigator (patent WO2017194761A2). This represents a very important breakthrough since this compound might serve as an ela
Glucose delivery systems for intervertebral disc repair – SLiGRIv
Low back pain is a widespread disorder that creates much patient suffering and exerts a tremendous economic burden on society. While this condition is multifactorial, intervertebral disc degeneration is one of its main causes. Degeneration starts in the compressible core of the intervertebral disc (
Sonoelectrochemical synthesis of calcium phosphate nanoparticles for injectable hydrogels – IXBONE
Our project is focused on bone regeneration after irradiation because it is a significant, real medical challenge that to date, represents an unmet clinical need. Moreover, the results obtained can be directly translated to all ischemic and hypotrophic bone regeneration needs. Interestingly, the pro
Evaluation in cynomolgus macaques challenged with SHIV-SF162-p3 of the protective efficacy of a measles-based SHIV vaccine combined with a peptide-based vaccine targeting 3 retroviral functions – ARTT-HIVAC
The repeated failures of previous clinical HIV-1 vaccine candidates and the moderate efficacy of the RV144 vaccine (31% at 42 months) have emphasized the need of new vectors inducing new immune functions and the setup of vaccine regimens combining several pre-existing immunogens/vaccine strategies.
Development of a therapeutic vaccine for allergic diseases – AllergyVACS
The incidence of allergies has dramatically increased over the last three decades in industrialized countries, with an estimate of 15% to 30% allergic patients in Europe and the US. Moreover, the World Health Organization now estimates that half of the people will develop allergies by 2050. Among al
Lipophenols, new anti-carbonyl and oxidative stressors to fight macular degeneration – LipoPheRet
Age-related macular degeneration (AMD) is a neurodegenerative pathology that affects photoreceptor cells during the production of a cytotoxic retinoid called A2E. This mechanism is also involved in genetic macular degeneration (Stargardt) through a dual carbonyl and oxidative stress. Based on promis
Antileishmanial agents targeting host cell trafficking – LeishmaStop
Leishmaniases are a complex of tropical and sub-tropical diseases provoked by Leishmania protozoan parasites transmitted by the sandfly vector and presenting different clinical expressions. In 2018, about 12 million Humans are affected by leishmaniases but global climate warming and population movem
Application for cancer therapy of the novel myeloid immune checkpoint receptor CLEC-1. – C_LECT_INHIB
One of the issues in the treatment of cancer is to destroy tumor cells without damaging healthy tissue. In recent years, immunotherapy has become the most promising approach to fight cancer: tumor cells can be targeted and destroyed by the immune system of the patient. It is clearly established now
A novel multi-stage acting antimalarial drug-candidate – plasmodrug
Malaria is still a major public health problem in 2018, since this infection due to the Plasmodium parasite, present in 91 countries, kills more than 440,000 people every year, with a majority of African children. As observed in most of infectious diseases, the emergence of resistant strains of P. f
Multiplexed nanovectors for metabolic liver fibrosis therapy – FIBROTHER
The aim of this project is to develop new siRNA nanovectors for hepatic fibrosis therapy. To date, liver fibrosis, which can evolve in cirrhosis or hepatocarcinoma, has no standard treatment. Liver fibrosis is a major consequence of chronic pathologies like hepatitis infection, alcoholism or metabol
Evaluation of the anti-CD115 mAb ELB041 to prevent lung fibrosis – MACROFIBRO
Lung fibrosis is a severe disease that develops after a viral infection, in response to aerosolized environmental toxins, in patients with a chronic inflammatory disease, or without any identified cause (idiopathic pulmonary fibrosis). It is also a complication of several commonly used therapeutic a