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Development of organoid culture systems to dissect human malaria liver infection – ORGANOMAL
Malaria remains a major cause of death and morbidity worldwide affecting 200 million people annually. Plasmodium falciparum (P. falciparum) is responsible for the majority of the 500,000 deaths attributed each year to malaria, but P. vivax, although less virulent, contributes significantly to malari
SEX-biased transmission and Infection dynamics in BATs – SEXIBAT
The emergence of zoonotic infectious diseases is a recurrent phenomenon with major public health and economic consequences. Some of recent outbreaks, such as those caused by Middle East Respiratory Syndrome and Ebola viruses, have highlighted the necessity of understanding processes driving the tran
PRedicting the ecological niche of human pathogens Infectious strains as a key determinant of infectious disease eMErgence – PRIME
The great majority of emerging infectious diseases (EIDs) are dominated by zoonoses (62 to 75%), with most of these being caused by pathogens with a wildlife origin. Among the 250 EIDs that affect humans, most are associated with areas of tropical rainforest, which provide EID ‘hotspots’, especially
Infections involving Candida biofilms: is the solution in lichens ? – LICSYFILM
The biofilm mode for survival and growth of microorganisms is now seen as a serious threat to public health. The American National Institute of Health (NIH) currently estimates that biofilms account for over 80% of all human infections. Due to their ubiquitous nature, biofilms are difficult to eradi
INTROGRESSION PHENOMENA IN THE STUDY OF THE GENETIC DIVERSITY OF TOXOPLASMA BETWEEN FRANCE AND WEST AND CENTRAL AFRICA: POSSIBLE ENVIRONMENTAL AND HUMAN INFLUENCES – IntroTox
Toxoplasma gondii infection is a ubiquitous zoonosis that affects all warm-blooded species. It has a complex epidemiology due to the wide range of hosts and transmission pathways involved. In human, it is generally benign in immunocompetent persons, life-threatening cerebral and multivisceral forms,
Predictive scenarios of health in Southeast Asia: linking land use and climate changes to infectious diseases – FutureHealthSEA
The project located in Southeast Asia aims at developing scenarios of future health embodied in the One Health approach at the human-animal-environment interface. By investigating the impacts of the intensification of the circulation along the economic corridor (Thailand-Laos) on the evolution of in
Dissecting the Antibody Cleavage System of Mycoplasmas – DACSyMy
Mycoplasmas are parasitic bacteria that are able to infect the majority of livestock animals, including cattle, goat, sheep, swine and poultry. The infected animal exhibit reduced production yields (loss of weight, limited milk and egg production), causing important economic losses to the farming in
Multi-Host Evolution of Avian Malaria in the Wild – EVOMALWILD
In recent years, the emergence or re-emergence of animal and human infectious diseases has been increasingly documented around the world. Ecosystem alterations, and movements of infected people and animals, provide new opportunities for host-parasite mixing, and can drive the introduction of both kn
“Night at the museum”: filling the gaps in the history of emergence of important crop pathogenic bacteria using historical material – MUSEOBACT
In order to better control current diseases of plants and prevent future epidemics, it is crucial to develop an improved understanding of the factors underlying pathogen emergence, adaptation and spread. Recent methodological developments in molecular epidemiology now allow tackling such question th
Reassortment, Emergence and Factor of Virulence of Influenza A Virus – REACTIV
Influenza A viruses are amongst the most challenging viruses for both human and animal health. The diversity of hosts that they can infect and the frequency of inter-species transmission events maintain the threat of the emergence of strains with high efficiency of spread among humans that could res
The Skin Secretome in the Antiviral Response against Arboviruses. – S2ARA
Arboviruses are emerging single-stranded positive-sense RNA viruses transmitted to, and pathogenic for, humans by blood-sucking arthropods, predominantly mosquitoes. The flaviviruses Dengue virus (DENV), West Nile virus (WNV), Zikavirus (ZIKV) and the alphavirus Chikungunyavirus (CHIKV) are responsi
Ivermectin against malaria: a one-health approach to treat humans and peridomestic animals with regard to minimal ecological side-effects – ANIVERMATE
The success of current control tools like Insecticide Residual Spraying and Long Lasting Mosquitocidal Nets is frequently undermined by peculiar behaviors of vectors allowing them to escape the exposure to insecticides. Exophagy and zoophagy minimize contact between mosquito and insecticides, and co
New insights into Escherichia coli pathogenicity: novel targets for antivirulence and immunomodulation approaches against urinary tract infections – UTI-TOUL
Urinary Tract Infections (UTIs) are among the most common infections worldwide, affecting one in two women. Symptomatic UTIs may be acute or recurrent, but Asymptomatic BacterUria (ABU) often also occur. Uropathogenic Escherichia coli (UPEC) are the bacteria responsible for 50–90% of all UTIs. Intro