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Periodontitis are inflammatory diseases of infectious origin leading to the destruction of tooth-supporting tissues. The prevalence of periodontitis is high in France and Europe. Chronic periodontitis has been associated to atherothrombosis and to acute cardiovascular events such as myocardial infar

Crohn’s disease and ulcerative colitis are severe inflammatory bowel diseases (IBD) that can end up in ulcer and fibrosis of the intestine. They are a worldwide health-care problem with a continuously increasing incidence. The available therapies are not curative, at best they provide temporary symp

Atopic disease affects 30-40% of the world's population, and the overall increase in their prevalence is a public health issue to date. Atopic dermatitis (AD) is the earliest and the most common manifestation of allergic diseases (prevalence 20%). AD is most often associated with food allergies (FA)

Lung cancer is the leading cause of cancer in France and worldwide. Recent therapeutic advances have come from identification of molecular alterations associated with efficacy of targeted therapies. Thus, discovery of new actionable molecular alterations is a major challenge. Recently, mutations aff

Given the continuous rise of diet-related chronic diseases worldwide, our timely translational project SINFONI, gathering international pluridisciplinary academic and industrial experts, develops a multifunctional anti-inflammatory dietary approach to improve cardiometabolic risk profile. Our novel

Out-of-hospital cardiac arrest is a leading cause of death worldwide. Therapeutic hypothermia (32-34°C) was proposed to improve the outcomes of patients after their resuscitation but it does not afford enough benefit with current techniques. Here, we propose a new paradigm for temperature management

Familial Mediterranean fever (FMF) is the most common hereditary systemic auto-inflammatory disease, classically transmitted as an autosomal recessive trait. This disease, which is particularly frequent in populations of Middle Eastern Mediterranean extraction, is also described in several other pop

Increasing evidences suggest that dysfunction of brain cholesterol metabolism plays a major role in neurodegenerative diseases particularly in Huntington disease (HD). Increased membrane cholesterol together with decreased activity of the cholesterol biosynthesis pathway (mevalonate pathway) are obs

Inflammatory bowel diseases (IBD), including Crohn's disease (CD), are contemporary conditions of industrialized societies. The global evolution of IBD implicates a potential sequence in the pathogenesis of IBD: Westernization alters environmental exposure that influences the microbiome that incites

Context Chronic heart failure (HF) is characterized by the inability of the cardiac pump to deliver enough oxygen and nutriments to the peripheral organs. Current therapy mainly targets the neurohormonal overdrive that is associated with this syndrome. Even with optimal treatment, mortality rates r

Urinary tract infections (UTIs) are among the most common of all infections, impacting more than 130 million people annually, worldwide. Nearly 50% of otherwise healthy adult women will have one UTI, and half of them will experience recurrent infection. Despite the extreme prevalence and economic bu

Membranous nephropathy (MN) is a rare autoimmune kidney disease, yet a major cause of nephrotic syndrome, with ~1,300 and 10,000 new cases per year in France and Europe, respectively. It is characterized by the accumulation of immune deposits on podocytes. Considerable advances have occurred in the

BK polyomavirus (BKPyV)-associated nephropathy (PVAN) remains an important cause of kidney transplant (KTx) dysfunction. There are few treatment options available for KTx recipients with sustained high level BKPyV viremia. Clinical management of PVAN relies on reduction of immunosuppressive therapy,

In most tropical areas where malaria is endemic, young children are most prone to develop severe malaria, and eventually to die. Despite a recent decrease in malaria mortality due to extensive malaria control through insecticide impregnated bednets and increased use of artemisinin derivatives, 275,0

Wet age-related macular degeneration (WAMD), characterized by the neo-vascularization of the retro-foveolar choroid, leads to blindness within few years. This disease is related to angiogenesis mediated by the Vascular Endothelial Growth Factor A (VEGF) and to inflammation. The only available treatm

Introduction: The auto-immune diseases are a major cause of morbidity. Usually, long time duration of immunosuppressant are needed to maintain the remission. Treatments are frequently associated with numerous side effects and the relapses frequently occur especially when the treatment is stop. Defin

Among vector systems that allow efficient in vivo gene transfer, recombinant adeno-associated virus vectors (rAAV) hold great promise. rAAV-mediated gene transfer in the muscle is promising for a variety of clinical applications and the first gene therapy product in the market is an intramuscular

Fragile X-associated tremor/ ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder characterized by progressive intention tremor, gait ataxia and cognitive decline. Nearly 1 in 4000 adult male has a lifetime risk of developing FXTAS, which make of FXTAS one of the most common single gen

Type 1 diabetes (T1D) is a chronic autoimmune disease mostly affecting children and young adults and resulting from the selective destruction of insulin-secreting pancreatic ß-cells by autoreactive T lymphocytes. Current treatment consists in administration of exogenous insulin, which is however imp

Dementia is a general term for decline in mental ability and cognitive dysfunctions severe enough to interfere with everyday life. Dementia encompasses different but often overlapping pathologies including Alzheimer diseases (60-80% of the diagnosed cases) along with Parkinson’s, Pick’s (also known

The role of B cells in the homeostasis of system biology in normal healthy individuals and in different processes of chronic inflammation (auto-immune diseases, cancer and transplantation) is now clearly established. Beyond their antibody secretion capacities, B cells can also present antigens, secr

Autoinflammatory diseases (AIDs) are rare genetic diseases beginning in childhood and characterized by recurrent episodes of fever with inflammation in the blood, arthromyalgia, gastrointestinal tract features, skin lesions and neuropsychological disorders. AIDs are linked to innate immunity abnorma

CKD is common affecting 10-12% of the adult population, and 30% or more over 70 years of age. Cardiovascular disease (CVD) is the leading cause of death in CKD patients with steadily increased risk as kidney function declines up to 10-20 times higher in end-stage renal disease (ESRD) than in the gen

Autoimmune and inflammatory diseases are a major public health problem worldwide. In particular, autoimmune and inflammatory renal diseases are the leading cause of renal transplantation in France and the third leading cause of renal replacement therapy by dialysis after hypertension and diabetes (R