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Mechanism of protein biosynthesis on ribosome studied by X-Ray analysis. – SSOR
1-Scientific background and objectives : The ribosome is a giant ribonucleoprotein cellular assembly (M.w. about 2 500 000 da) that translates genetic code into protein in living cells, and consists of two subunits in all species. A complete understanding of protein synthesis requires knowledge of t
Fluorescence lifetime imaging of Rho-GTPase activation in the living fly brain: from molecule to memory trace – RhoGTPFLIM
Neurones sur nanotransistors: des systèmes vivants instrumentés pour les neurosciences. – NeuroFET
Mechanical stress in T cell activation and immunological synapse formation using magnetic colloidal tools. – MeTIS-Mag
Study of the molecular and cellular actions of oxysterols and oxaphosphinanes against glioblastoma – G2O
Spatio-temporal control of protein dynamics in living cell using original two-photon sensitive caged fluorophores – Caged-fluo
Probing the Signaling Functions of a Krebs-Cycle Intermediate: Signal Transduction and Metabolome – ProKrebs
New Olfactory SEnsors : Molecular mechanisms of odorant detection, and application to lab-on-chip biosensors – NOSE
Nano-Cryo-Electron and Spectral Imaging of Water and Ions in the Nucleus – Nano-CESIWIN
Development of membrane proteomic tools using GPCRs as models – MS4MeP
Development of smart bioagents armed for molecular imaging of vulnerable plaques in atherosclerosis – IMATHABIO
Deciphering global gene regulation by a chromatin structural protein in bacteria – HNSTRUC
Pseudo-peptides for transfection : Chemical synthesis, biophysical analysis of supramolecular complexes and biological assays – TRANSPEP
Mechanistic and inhibitory studies on novel thymidylate forming enzymes – THYMET
Conformational Dynamics in Folded, Partially Folded and Natively Unfolded Proteins in the Solid and Liquid State – PROTEIN MOTION
Role of the plus-end tracking proteins (+TIPs) in microtubule capture – TIPS
Fluorinated surfactants for membrane protein biochemistry and biophysics – PROMEMSURFII
Design of Immobilized Phosphorus HEterocycles for Lipase INhibition and Enzyme Capture in Complex Biological Materials – PHELIN
Investigation of reciprocal crosstalk between cadherins and integrins : a micromechanical study – CrossInteCad
Structures and Dynamics in the Regulation of Nuclear Receptor Function – 3DYNUR
A multivalent peptide library approach to identify functional TRAIL mimetics – ApoMULTI-LIB
1-Scientific background and objectives : The modulation of cell signaling by small molecules, designed to interfere with pathological processes to induce a therapeutically beneficial effect is a major challenge which necessitates a multidisciplinary effort. Current cancer therapy follows treatment p
Engineering synthetic nucleases for genome modification – SYNMOD
By conjugating DNA-code reading molecules to reagents that induce DNA breaks, we propose to synthesize novel sequence-specific nucleases. We will characterize their cleavage activity in living cells and test their application in targeted genome modification. The conjugates that we already synthesize
Atomic Force Microscopy-assisted modeling of macromolecular assembly – AFM-Assembly
1- Scientific background and objectives: - Post-genomic era has accelerated structure determinations of proteins from a large variety of organisms. There are more than 86000 known protein structural domains. The challenge in facing biology is now to understand how these domains assemble to form larg
Dynamic structures of SNARE transmembrane domains and lipids in membrane organization and their function in exocytosis – EXODYNAMICS
Scientific background and objectives Understanding biological processes in protein-lipid membranes represents a major challenge as membrane proteins constitute 2/3 of all drug targets and are essential for major cell functions. Due to the inherent difficulties in structural studies of membrane prote
New Lab-on-Chip for the enantiospecific analysis of free D-amino acids in biological fluids – D-AminoChip
1-Scientific background and objectives : - D-enantiomers of amino acids play a preponderant role in biochemistry and especially in - neurotransmission. For example, D-serin is involved in neurological diseases evolution, such as - schizophrenia or epilepsy. The presence of D-aspartate has been de
Mass Spectrometry Specific Imaging of Biomolecules – BIOSPIM
Mass spectrometry has become an unavoidable tool for biomolecules characterization allowing complex mixture analyses, in a short time, with high sensitivity and structural characterization. Thus, in the era of proteomic and high throughput analyses, it plays a key role in biological research. Howeve
Vectorisation de radioéléments pour la radioimmunothérapie des tumeurs solides de petite taille – VecRIT
CHIMIE ET PHARMACOLOGIE DES GYMNODIMINES, SPIROLIDES ET DE LEURS ANALOGUES – NEUROSPIROIMINE
Elaboration de marqueurs fluorescents à 2 Photons optimisés : Application au Traçage d'Acides Nucléiques en milieu cellulaire – EPATAN
Aminoglycosides antiviraux ou antibiotiques agissant sur des bactéries résistantes (maladies nosocomiales) – aminosides
Ligands neutralisants de chimiokines – neutraligand
Stéroides et obésité – STEROB
Optimisation de la stabilité de matériaux biologiques pour de nouvelles stratégies thérapeutiques. – BIOSTAB
Elaboration d'immunocapteurs de toxines/bactéries en milieu alimentaire : nouvelles stratégies et validation en milieu réel. – Biocaptox