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Antisense sequences delivery for therapeutic intervention on messenger RNAs – GENESPLICE
Therapeutic exon-skipping was obtained in the skeletal muscle of diseased mice and dogs and in cells from human [...] antisense or interfering RNA (shRNA) in the skeletal muscle to further define the tolerance of Dystrophin for
Development and Physiopathology of the digestive tract – DIGEST
on the pathways involved during visceral smooth muscle cell differentiation. This differentiation is often [...] control the gut development and the visceral smooth muscle cell differentiation. We plan to use the chick [...] during the differentiation of the visceral smooth muscle cells in the stomach. Are the FGF signaling pathway
Innate immunity and skeletal muscle repair and homeostasis – Myo-repair
beneath the basal lamina of muscle fibersWe established that, in muscle, quiescent sub-laminal SCs are [...] Muscle tissue repair is a most complex biological process that prominently involves activation of myogenic [...] are stably located close to muscle capillaries, and vary in number proportionally to capillarization.This
MOLECULAR SYSTEM BIOENERGETICS – MOLSYBEN
in living cells. The intracellular medium in muscles is highly organized and macromolecules and organelles [...] n is the system of energy transfer networks in muscle and brain cells. The important task of highest [...] processes between different cellular compartments in muscle cells will be developed. Mathematical model of
MOdèles et Méthodes Mathématiques en Electrocardiologie – MOMME
heart. Yet very complex mathematical models of the muscle tissue are now known and lead to expensive and
Metabolic alterations associated with UCP3 gene expression in skeletal muscle – MetUCP3
electron chain transport in skeletal muscle at rest and during muscle activity. We will use an original [...] skeletal muscle function in situ using magnetic resonance techniques and measurements of muscle performance [...] highly and preferentially expressed in skeletal muscle and would play a major role in whole body epin
Myotubularinopathies : common molecular mechanism and tissue specificity – MTMPATHIES
myelination of axons or disorganization of the skeletal muscle fibers, respectively. MTM1 and MTMR2 are phosp [...] MTM1 and MTMR2 proteins, respectively in skeletal muscle and Schwann cells. The three partners gathered [...] expertises on phosphoinositides metabolism, and muscle and myelination pathology. We propose : -to study
Nano-mécanique de fibres & films de soie – Nanosoie
study is indispensable in the understanding of muscles or ligaments. From the scale of the macromolecule
Rôle et importance des contrôles post-transcriptionnels de l'expression génétique dans la segmentation somitique des vertébrés – SEGPOSREG
Somitic cells will evolve in adults in skeletal muscles, bones and derm. Somites are organised in a segmented
Selective inhibition of Schistosoma mansoni guanidino kinase as potential new therapeutic target for the treatment of bilharzia – SmGKinhibit
report of novel and original inhibitor of mammal muscle creatine kinase (CK), the mammal homologue of SmCK