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Crosstalk of Glucocorticoid Receptor and AMP-activated protein Kinase in macrophages during inflammation and tissue repair – GR-AMPK
activation is required for a proper repair of damaged muscle by inducing an anti-inflammatory phenotype in [...] evidence that i) GC-treated macrophages influence muscle repair dependent on AMPK in vitro, that ii) an [...] inflammation model (non sterile inflammation) and in a muscle repair model (sterile inflammation) how AMPK c
SUStainable production of HIgh quality aquaculture FISH using innovative tools and production strategies and integrating controlled slaughter and novel processing methods and cold chain management – SUSHIFISH
egg/larval imprinting strategies to improve growth and muscle quality and by monitoring and reducing chronic
Regulation of myogenesis by the extracellular matrix - application to the use of matrix scaffolds for reparation of large skeletal muscle lesions – Myo-MECa
Skeletal muscle regenerates after an injury thanks to the muscle stem cells as well as to neighboring [...] proposal aims at repairing large muscle injury via the adjunction of muscle-derived matrix biomaterial, which [...] involved in muscle regeneration. Literature shows that ECM plays an important role in muscle regeneration
Understanding the PROtectiVe Inflammation in DiabEtes – PROVIDE
The overall objective of the proposed project is to reveal the physiologic role of inflammation dependent of IRF5 pathways in the adaptation to metabolic stress linked to T2D. Understanding the physiological and the pathological role of the immune system may allow designing personalized treatments promoting a beneficial immune status in patients with T2D.
Identification of biomarkers of beta-cell stress and inflammation by exploring inter-organ communication inpreclinical models of obesity and type 2 diabetes – betadiamark
glucose uptake and utilization by liver, fat, and muscles. The balance between insulin secretion and action [...] tissue (visceral and subcutaneous depot), skeletal muscle (soleus and tibialis anterior) will be isolated
Going beyond the limits of myoelectric upper-arm prostheses: phantom hand movements for natural control – PhantoMovControl
of functionally distinct muscle volumes within the same muscle, i.e., muscle volumes that are distinctly [...] associated to specific activities of residual limb muscles according to the type of performed phantom movement [...] use these patterns of activation of the distinct muscle volumes to make the prosthesis mimicking the executed
Social dimension of primates’ peripersonal space – MySPACE
The aim was to shed new light on the social modulation of space close to the body, by exploring its behavioral determinants and neural markers. In our social world, a comfort zone is necessary to regulate the distance between oneself and others and to avoid discomfort. Our hypothesis was that the space of communication and interaction with social information close to the body reflects an integration of our goals and our internal state.
Study of a putative novel respiratory center – Phox2RESP
This project aims at deciphering the function of a new group of putative respiratory neurons in the hindbrain of the mouse: peri-trigeminal neurons (Peri5). Using genetic tools derived from developmental studies, we will map the connectivity of the Peri5 neurons, target specific mutations to them and characterize their function in reduced ex vivo and in vivo preparations.<br /><br />
Design of a novel class of biodegradable and functionalized polyesters for cardiac application – NANOCARDIOROP
cross-linked polyesters to promote contractile muscle formation limiting the remodeling process and therefore
FGF21 links hepatic ChREBP and PPARa to systemic glucose control – Hepatokind
beneficial action in peripheral tissues (skeletal muscles, white and brown adipose tissue) and in pancreatic