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transferrin and ocular therapy – oculotransferrine
antibodies. 2- to tranfect directly the ciliary muscle with plasmids carrying the Tf gene or part of it
Role of actomyosin system in normal and pathological megakaryopoiesis – MyoMeg
specific or redundant roles of MYH9 and another non muscle myosin II (NMII) isoform MYH10, which is identified
System bioenergetics of cardiac cell pathology – SYBECAR
advances, cardiovascular diseases and skeletal muscle involvement in chronic pathologies and neurode [...] Alteration of these interactions may result in muscle cell pathology (myopathy). Intracellular struc [...] on the degree of cells differentiation, type of muscle cells and their health/pathology state. One interesting
Piezo 1 and arterial mechanotransduction – PIEZO
The myogenic tone is inherent to vascular smooth muscle cells (VSMCs) and is independent of the endothelium
Development of a stem cell-based nanostructured implant for osteochondral repair – nanoOSCAR
mesoderm, the embryonic tissue from which skeletal muscle, dermis and axial skeleton are derived. These
Role of the chromatin dynamics on the stochasticity in gene expression in higher eukaryotic cells – STOCHAGENE
Gene expression is an inherently random phenomenon that challenges the view of the cell as a small computer, subjected to the orders of a «genetic program.«
Mechanosensation and mechanostabilization during embryonic morphogenesis – SenStable
inputs from muscles. We could very recently identify the nature of this input, showing that muscle contractions [...] depends on two tissues, the epidermis and body muscles. C. elegans embryos provide a paradigm to study
Sleep, Cognition and Alzheimer – SCOAL
Recent studies suggest that sleep disorders precede over the years the onset of clinical signs of Alzheimer's disease (AD).
Molecular basis of immune tolerance after gene transfer – Gene_Transfer_Tolerance
Clear clinical success have now been obtained by gene therapy approaches. The patient's immune system may, however, reject the injected product perceived as foreign, and thus limit its effectiveness. This project aims to understand the basis of this rejection and determine how to overcome it to reach a state of immune tolerance.
MR guided cardiac RF ablation – TACIT
procedure. Insufficient energy delivery to the cardiac muscle may lead to incomplete (non transmural) ablation [...] lar explosion (pop) and rupture of the cardiac muscle leading to tamponade. In addition, extracardiac