Search for a funded project
Mechanisms defining functional heterogeneity of anatomically distinct myogenic populations – MUSE
myofibers to restore muscle function. An unexpected heterogeneity between head and trunk muscles exists in view [...] committed muscle cells depending on their anatomical location remains unknown. Cranial muscles, and s [...] uninjured muscles. The global objective of MUSE is to provide an integrated view of muscle heterogeneity
Adipose tissue-derived progenitors are essential protagonists of Skeletal Muscle Regeneration – ARMURE
understand that defects in muscle regeneration, leading to loss of muscle function, can be massively [...] partner for muscle regeneration. Understanding the benefit of these adipocytes for muscle regeneration [...] ARMURE application is interested in skeletal muscle biology with specific emphasis on the regenerative
Role of Neuronal signaling pathways in promoting intestinal smooth muscle maturation – NeuroPIMM
interplay between ENS and muscle progenitor cells regarding smooth muscle development and function remain [...] These movements originate from layers of smooth muscles that rhythmically contract through the coordination [...] complex behaviors of the gut by controlling smooth muscle contractions (or peristalsis) and changing the
Consequence of senescence in muscle regeneration and degenerative myopathies – SenoMuscle
senescence and muscle regeneration. However, the mechanisms by which senescence regulates muscle regeneration [...] unknown. The regeneration capacity of the skeletal muscle declines significantly during aging. Duchenne muscular [...] characterization of the senescence program on muscle regeneration, with focus on factors that control
Interferon-mediated impairment of myogenic epigenetic regulation in inflammatory myopathies – IFN-Epi-IM
data show that: a) IM-derived muscle stem cells (MuSCs, which sustain muscle regeneration), exhibit myogenesis [...] the disease severity. Although most patients have muscle defects that resist to treatments, myogenesis has [...] understand the consequences of the IFN response on muscle homeostasis in order to propose a proof of concept
Dysregulation of Type I interferon signalling in Juvenile Dermatomyositis: from pathophysiology to new biomarkers. – JDMINF2
analysis. Muscle biopsies will be studied using the first protocol of spatial RNAseq on human muscle tissue [...] generated from muscle biopsy spatial RNAseq will provide a template to study muscle responses to in [...] relapsing or chronic disease leading to persistent muscle weakness and disability. The disease is characterized
Genetic and molecular determinants of muscle ageing – MUSAGE
Thus, deciphering the limiting factors that cause muscle aging is a major public health issue. MUSAGE project [...] project aims to identify mechanisms responsible for muscle aging by novel approaches in C.elegans. Based on [...] allowed us to identify unexpected regulators of muscle aging that are conserved through species. Based
PREVENTING DIAPHRAGM DYSFUNCTION IN THE INTENSIVE CARE UNIT WITH INNOVATIVE ULTRASOUND BIOMARKERS – ULTRADIAPH
soulage le travail des muscles respiratoires, notamment du diaphragme, le principal muscle de l’inspiration [...] largement, les muscles inspiratoires et expiratoires accessoires. La surveillance des muscles respiratoires [...] suscite un intérêt croissant pour l'évaluation des muscles respiratoires. Cependant, l'échographie est très
Modulation of myofibers integrity and function in health and disease – Atrorescue
Muscle dysfunction is implicated in a plethora of human diseases and in sarcopenia, i.e. muscle atrophy [...] project aims at identifying important pathways for muscle intracellular organization, under physiological [...] and pathological conditions. The function of the muscle fiber (myofiber) is supported by a precise positioning
Clathrin plaques: Structure, function and implication in neuromuscular diseases – CLASS
clathrin-coated pits for fast endocytosis at synapses, muscle cells form large flat clathrin-coated plaques for [...] costameres, a cornerstone of mechanotransduction in muscle through their role as physical and functional links [...] a specialized function for clathrin plaques at muscle costameres, one fundamental question remains: Why