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Cellular and molecular dynamics of muscle stem cells during muscle hyperplasia decline in trout – FishMuSC
Skeletal muscle consists mainly of muscle fibers formed during embryonic and fetal development. Except [...] zebrafish. Muscle hyperplasia requires the proliferation and the differentiation of muscle stem cells [...] arises from muscle stem cells also called satellite cells. However, the hyperplasic muscle growth declines
Functional connectomics of postural motor control – FuCPoC
descending motor pathways, which would allow muscle-to-muscle adjustment, remain to be characterized. We [...] ive sensory feedback from a specific muscle or group of muscles. We will then investigate the neurons [...] which link these sensory and motor circuits muscle to muscle. On the one hand, we will use retrograde
Characterization of Lsd1 function in glucocorticoid-induced muscle atrophy – LSD1GR
glucocorticoid-associated muscle wasting and that Lsd1 interact with GR in skeletal muscle, suggesting that Lsd1 [...] role of Lsd1 in muscle fibers in basal conditions and in glucocorticoid-induced muscle atrophy, and to [...] limited by adverse effects, such as diabetes and muscle wasting. LSD1GR aims at reducing such side effects
Laser-assisted stem cells bio-printing for regenerative medecine – ICELARE
stem cells applied to muscle differentiation. The contractile function of the muscle can be modified in [...] advances in muscle repair medicine and the modelling of acquired or congenital muscle pathologies using [...] develop. In particular, we target the optimization of muscle cell differentiation and the formation of active
A novel quantitative magnetic resonance imaging protocol for comprehensive evaluation of skeletal muscle tissue structure in muscular dystrophy – MR-MyoMap
evaluation of the skeletal muscle tissue structure (including respiratory muscles in free-breathing conditions) [...] the degree and, more importantly, the pattern of muscle involvement. This modality is also helpful for [...] for guiding other diagnostic procedures, such as muscle biopsy. Beyond its diagnostic value, and similarly
Keep walking : Maintenance of muscle innervation – DevandMaintain
Each motoneuron axon terminal innervates specific muscle fibers and displays an unique architecture defined [...] axon terminals ensure the proper contraction of muscles allowing a correct and stereotyped locomotion. [...] During adulthood, the maintenance of muscle innervation is essential to keep the locomotor system functional
MBNL loss of function and motor unit dysfunction in Myotonic dystrophy – Motor-DM
neurons (MN) and the skeletal muscle via neuromuscular junctions in muscle dysfunction in DM1. Using mice [...] and function knowing that MN controls skeletal muscle activity. The proposal will a better understanding [...] loss of function in MN and its contribution to DM1 muscle pathophysiology.
Single-cell Spatio-Temporal profiling of cellular subfractions in Duchenne Muscular Dystrophy – Model_DMD
most severe pediatric degenerative myopathies. DMD muscle is constantly exposed to cycles of degeneration [...] transcriptomics to obtain a cellular atlas of skeletal muscle. In Model_DMD I now propose to capitalize on this [...] interfering with regeneration in the dystrophic muscle. The overall goal of this proposal is to gain critical
Biomimetic control of prosthesis using residual movements and contextual information – CoBioPro
typically controlled by the activity of two residual muscles, and are reimbursed by social security. However [...] a higher number of joints with fewer residual muscles. Together with the lack of sensory feedback, the [...] focusses on myoelectric control based on residual muscle activities, a promising alternative aims at exploiting
Molecular and cellular mechanisms underlying the diversity of connective tissues – LimbCT
existence of chicken limb cells exhibiting a hybrid CT/Muscle identity (scRNAseq data) and an unexpected contribution [...] development (fibrogenesis). Tendon and irregular muscle CT are 2 CTs associated with major clinical challenges [...] challenges, such as tendon scarring following injuries, muscle dystrophies, respectively; pathological situations