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Role of TGF beta family members in muscle wasting : towards innovative therapeutical approaches – TGFMyo
TGF-b superfamily ligands, such as myostatin, are potent negative regulator of muscle mass. Contrasting with classical loss of function approaches (receptor knockout), we will develop an unbiased mouse model to explore the cell autonomous effects of TGF-b signaling on muscle, through the expression of a Cre-inducible constitutively active type 1 TGFß receptor in muscle cells.
AHR activation and mechanisms of cell alteration in myasthenia gravis model – ATM
impairs nerve-muscle transmission with subsequent consequences on muscle regeneration and muscle stem cell [...] adaptation to physical training and in muscle regeneration (muscle stem cells (MuSC)). In the ATM project [...] induces, in the muscle tissue, an exacerbation in disease course by altering muscle stem cell function
Systematic functional analysis of mitochondrial dynamics in healthy young, aged and sarcopenic muscle – MITO-DYNAMICS
In the MITO-DYNAMICS project, we aim to identify mitochondrial processes and their regulators responsible for muscle wasting (sarcopenia) during ageing and in disease conditions. <br />We proposed a systematic and quantitative approach to understand the molecular, morphological and physiological dynamics of mitochondria comparing young, old and sarcopenic muscles of mice and flies. This will be complemented by the development of an integrative analysis platform, mitoXplorer.
Modelling cachexia in drosophila – CADRO
Cachexia, or dramatic and rapid wasting of muscle and adipose tissue that cannot be compensated for by [...] (inducers and targets), and different organs (muscles, adipose tissue, central nervous system ...), requires [...] and have shown that pharmacological blockade of muscle wasting prolongs the survival of mice with experimental
Morphogenesis of two active tissues in contact, a multi-scale mechanical analysis – EpiMorph
contracting muscles and the outer epithelium. We will: (i) Measure the deformation experienced by muscle cells [...] tension experienced by muscle cells using a FRET tension biosensor based on talin (a muscle protein), and by
ENTERIC NERVOUS SYSTEM NEURONS AS A TARGET TO TREAT TYPE 2 DIABETES: ROLE OF BACTERIAL BIOACTIVE LIPIDS – ENDIABAC
ns of mechanical activity of intestinal smooth muscle cells, which are under the influence of enteric [...] informs the brain to block glucose entry in the muscle. Therefore, the modification of the activity of [...] 2) a “central” effect on glucose utilization in muscle via a hypothalamic nitric oxide (NO) relay. A
Biological functions of the histone variant H2A.Z – ZFun
in both skin development and ageing of skeletal muscle. Methodology: This is an interdisciplinary project [...] both H2A.Z isoforms in either skin or skeletal muscle, to analyze the resulting phenotypes and to uncover [...] uncover the role of H2A.Z in skin renewal and muscle ageing. Consortium: The project is an interdisciplinary
Valuing the plant proteins as blends of high nutritional quality for spécific population. Proof of concept with a new product designed for preventing metabolic dysfunctions in the elderly – P-Probs
Modern societies are converging towards Western diets rich in animal products, sugars and saturated fats, combined with low levels of physical activity. Thus in 2050, the growing world population will consume 60% more animal protein. However, the industrialization of livestock farming and its environmental impacts, the rise of chronic diseases and the degraded image of animal industries are questioning the share of animal proteins in our diets.
Therapy by modulation of Dynamin 2 expression – DynaTher
characterized by abnormal centralization of nuclei in muscle fibers. Three main forms of CNM are distinguished: [...] efforts of the two teams supported by the “DynaMuscle” ANR program led to essential breakthrough for [...] disorders? Therapeutic benefit of reduction of the DNM2 muscle-specific isoform will be determined in Knock-out-Mtm1
Exascale simulation of cardiac electrophysiology to support arrhythmia research – Exacard
activation system of the heart. In each cardiac muscle cell, millions of molecular-scale ion channels [...] serve to synchronize the contraction of the heart muscle. Pathologies that affect this intricate system [...] each element still represents hundreds of cardiac muscle cells. This resolution suffices to simulate a