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In vivo quantification and manipulation of mechanical forces across muscle attachment sites and sarcomeric proteins during muscle morphogenesis – MUSCLE - FORCES
myofibrils, which span the entire muscle fiber. Both muscle fiber ends are attached via tendon cells to the [...] simultaneously throughout the entire muscle fiber during muscle development. Thus, the earliest myofibrils [...] myofibrils already span the entire muscle and are anchored at the muscle attachment sites to tendon cells
Adult skeletal muscle stem cell regulation by Bone morphogenetic protein signaling – BMP-MYOSTEM
Adult skeletal muscle possesses the ability to fully regenerate and this depends on the presence of quiescent [...] quiescent muscle stem cells, so-called satellite cells that lie in juxtaposition with each myofiber and [...] injury and form progenitors to replace degenerated muscle fibers. Understanding signaling cues that regulate
Genetic and epigenetic control of adult muscle fiber type – MYOLINC
both down-regulation of slow muscle genes and up-regulation of fast type muscle genes? Knowledge of linc-Myh [...] In adult skeletal muscles, myofibers are classified based on their contraction velocity, a property that [...] that only a single Myh gene is expressed in the muscle fiber. We currently lack an understanding of
Calpain : a new target for the treatment of spasticity after a spinal cord injury. – CalpaSCI
characterized by hyperreflexia and stiffness of muscles. Spasticity results from alterations in motoneurons [...] results from a dysregulation of Cl- homeostasis. In muscles, spasticity induces stiffness by calpain activation [...] excitatory/inhibitory imbalance and stiffness of the muscles. Ultimately, an effective and minimally invasive
Bioinspired chitosan cardiac patches: assemblies with the secretome of Mesenchymal Stem Cells for cardiac tissue regeneration – MYOCHITO
Bioinspired polysaccharide-based patches for the regeneration of the myocardium
Characterization of the molecular mechanisms underlying steroid hormone receptor cross-talk – AR2GR
s, muscle wasting and myopathies. Moreover, the anabolic effects of androgens on skeletal muscles are [...] development of sexual characteristics, behaviour and muscle mass and strength, whereas glucocorticoids control [...] are of interest to improve muscle function in elderly men and in patients with various diseases, including
Modified MBNL gene therapy targeting nuclear expanded-CUG repeats to counteract toxic RNA gain-of-function in Myotonic Dystrophy – THERADM
a hallmark of DM1 disease affecting skeletal muscles is also abolished. Our project is to develop an [...] as physiological effects of local (brain, heart, muscle) but also systemic MBNL? delivery will be assessed
Physiologic and pathologic SMYD3 lysine methylation signaling – S3S
differentiation as well as in skeletal and cardiac muscles formation. Its activity has been linked to the [...] contexts with evidences of SMYD3’s implication: muscle formation and regeneration, and pancreatitis.
Chaperone-Histone Determinants of Cell Identity, Lineage Fate and Transitions – CHIFT
primary cells and tissue. We will focus on adult muscle lineage progression from stemness to renewal, to [...] particular attention to asymmetrically dividing muscle stem cells, to dissect how repartition of parental
Increasing survival and protecting the kidney by using a sinlge dose of Estrogen during hemorragic shock and rhabdomyolysis – ESTROCHOC
shock and rhabdomyolysis (large destruction of muscle cells) are among the most frequent and serious [...] withers. However, degradation products released by muscle cells frequently induce an acute tubule-interstitial