Search for a funded project
Bone-Muscle cross talks in musculoskeletal regeneration – Bone-Muscle-Repair
hand and the repair of muscle on the other hand. Although bone and skeletal muscle injuries trigger very [...] systems from bone and muscle. Our preliminary data strongly suggest that bone-muscle bidirectional interactions [...] in these bone-muscle cross talks, as it lies at the interface between bone and muscle. We propose 3 aims
Specification and realization of muscle identity in Drosophila – Muscle-Identity
Specification and realization of muscle identity, Model studies in Drosophila. <br />The morphological diversity of skeletal muscles underlies animal locomotion. Gene Regulatory Networks directing generic myogenesis have been decrypted in mammals, The control of each muscle morphological identity remains a fundamental and bio-medical issue, with human myopathies affecting distinct sets of muscles. <br />Muscle-Identity aimed at establishing a global view of this control, using an insect model.
Role of Serum Response Factor as a mediator of mechanotransduction in skeletal muscle homeostasis – MECHANO
that regulate gain and loss of muscle mass is crucial for treating muscle wasting associated to conditions [...] ation, denervation) lead to muscle atrophy and increased loads to muscle hypertrophy (compensatory h [...] signaling pathways that control muscle mass, the molecules that translate muscle load into signals that support
Acetylcholine receptor gene coregulation by long distance interactions – COLOC_ACHR
The muscle cell is unique as it contains several nuclei which organize their genome in different ways depending from their position and activity. We aim to understand how and why genome organization changes during muscle differentiation.
Optogenetic control of the neuronal network responsible for paradoxical (REM) sleep atonia – OPTOREM
Paradoxical sleep (PS) is characterized by an atonia of the whole somatic musculature sporadically interrupted by muscle twitches. The identification of the mechanisms controlling the motor activity during PS is clinically relevant since an abnormal regulation of the muscle tone occurs in three of the major disabling sleep disorders, i.e. REM sleep behavior disorder (RBD), narcolepsy with cataplexy or obstructive sleep apnea (OSA).
Short telomeres in patients at high cardiovascular risk: a simple marker or a major determinant of accelerated arterial aging – TELARTA
-TL in skeletal muscle mainly reflects TL at birth -The difference in TL between muscle and leukocytes [...] dynamics in different tissues: leukocytes, skeletal muscle, endothelial progenitor cells (EPCs) in patients [...] as expressed in the difference between TLs of muscle and leukocytes. Specific objectives: 1: To determine
Stimulating Intrinsic Repair for DMD – SIRD
humanized DMD muscle. These experiments will advance our knowledge of Wnt7a signaling in muscle and illuminate [...] manifested by progressive debilitating skeletal muscle weakness and wasting, and ultimately death. The [...] Wnt7a/Fzd7 signaling in stimulating the regeneration of muscle by acting at two levels. Wnt7a acts on satellite
Desmin involvement in mechanical properties of skeletal muscle cell – DESMECA
transmission of mechanical forces through the cell. In muscle, it is well established that desmin intermediate [...] contribution of the I.F. network to the behavior of muscle cells in the presence of mechanical stress remains [...] determining whether the mechanical properties of muscle cells (myoblasts, myotubes and myofibers) and their
Rhabdomyolysis: pathogenic mechanisms of lipin-1-dependent disease in human and animal for therapeutic perspectives – RHAB
abundantly expressed in adipocytes and skeletal muscle and plays a dual role, i) a phosphatidate phosphatase [...] hypertriglyceridemia and peripheral neuropathy while muscle symptoms are predominant in human. The myolysis [...] drawbacks. First, the function of lipin-1 in skeletal muscle growth and metabolism is largely unknown. Second
IntEgrins alphav in VAscular smooth muscle cells: cross-talk mechanisms linking arterial Stiffness with thrombin generatION within the vessel wall – EVASION
IntEgrins alpha v in VAscular smooth muscle cells: cross-talk mechanisms linking arterial Stiffness with thrombin generatION within the vessel wall