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Control of skeletal muscle mass by Bone Morphogenetic proteins – BMP-MyoMass
skeletal muscle mass depend on the presence of muscle stem cells, their ability to generate muscle fibres [...] network defines the rate of muscle growth, final muscle size and number of muscle stem cells inherent to adult [...] skeletal muscle. • Understand the role of BMP signalling during muscle atrophy and during muscle regeneration
INNOvations in elastography to quantify Viscosity and ANisotropy of muscle – INNOVAN
describe the 3D behavior of the muscle and are not able to account for muscle anisotropy due to fibers. This [...] limitation because the muscle fibers move in the 3D space, inducing a bias on 2D muscle SWE measurements. [...] that the muscle tension level would increase both elastic and viscous anisotropy of muscle (hypothesis
Role of TGF beta family members in muscle wasting : towards innovative therapeutical approaches – TGFMyo
TGF-b superfamily ligands, such as myostatin, are potent negative regulator of muscle mass. Contrasting with classical loss of function approaches (receptor knockout), we will develop an unbiased mouse model to explore the cell autonomous effects of TGF-b signaling on muscle, through the expression of a Cre-inducible constitutively active type 1 TGFß receptor in muscle cells.
Bone-Muscle cross talks in musculoskeletal regeneration – Bone-Muscle-Repair
hand and the repair of muscle on the other hand. Although bone and skeletal muscle injuries trigger very [...] systems from bone and muscle. Our preliminary data strongly suggest that bone-muscle bidirectional interactions [...] in these bone-muscle cross talks, as it lies at the interface between bone and muscle. We propose 3 aims
In vivo analysis of muscle stem cells vascular niche – MyoStemVasc
ns with muscle stem cells during the regeneration of skeletal muscle and in diseased muscle. [...] Skeletal muscle regenerates after injury, due to the satellite cells (SCs), the muscle stem cells that [...] that vascular smooth muscle cells and pericytes regulate SC quiescence during muscle post-natal growth.
Specification and realization of muscle identity in Drosophila – Muscle-Identity
Specification and realization of muscle identity, Model studies in Drosophila. <br />The morphological diversity of skeletal muscles underlies animal locomotion. Gene Regulatory Networks directing generic myogenesis have been decrypted in mammals, The control of each muscle morphological identity remains a fundamental and bio-medical issue, with human myopathies affecting distinct sets of muscles. <br />Muscle-Identity aimed at establishing a global view of this control, using an insect model.
Mechanisms defining functional heterogeneity of anatomically distinct myogenic populations – MUSE
myofibers to restore muscle function. An unexpected heterogeneity between head and trunk muscles exists in view [...] committed muscle cells depending on their anatomical location remains unknown. Cranial muscles, and s [...] uninjured muscles. The global objective of MUSE is to provide an integrated view of muscle heterogeneity
Pathophysiological mechanisms of androgen and glucocorticoid receptors in skeletal muscle, and identification of new drug targets for prevention and treatment of muscle atrophy. – Androgluco
the identified AR and GR targets in muscle that control muscle mass and/or strength will be potential [...] Skeletal muscle is a dynamic tissue that has the capacity to regulate its size and function in response [...] response to a variety of external clues. Muscle inactivity, fasting, diseases (e.g. AIDS, cancers, septic
Regulation of myogenesis by the extracellular matrix - application to the use of matrix scaffolds for reparation of large skeletal muscle lesions – Myo-MECa
Skeletal muscle regenerates after an injury thanks to the muscle stem cells as well as to neighboring [...] proposal aims at repairing large muscle injury via the adjunction of muscle-derived matrix biomaterial, which [...] involved in muscle regeneration. Literature shows that ECM plays an important role in muscle regeneration
Cellular and molecular dynamics of muscle stem cells during muscle hyperplasia decline in trout – FishMuSC
Skeletal muscle consists mainly of muscle fibers formed during embryonic and fetal development. Except [...] zebrafish. Muscle hyperplasia requires the proliferation and the differentiation of muscle stem cells [...] arises from muscle stem cells also called satellite cells. However, the hyperplasic muscle growth declines