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Functional genomics to dissect complex human lupus phenotype – LEDsGO
Trying to understand the mechanism of the different phenotypic traits of lupus, a severe and heterogeneous autoimmune disease, is a huge and essential effort to lead to the development of new therapeutic targets. We have developed new transgenic murine models, with deregulation of gene expression as observed in lupus patients, which we propose to analyse in this project to better understand the mechanisms of this disease.