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Seing the invisible, or, how to integrate metadynamics in the quantitative analysis of protein/protein complexes right at your fingertips. – METADYN
present in all biological processes. Indeed, a key feature defining protein function in living cells is their
Virtual Reality for Training Doctors to Break Bad News – ACORFORMed
interaction model, including verbal and non-verbal features. No such model already exists, whatever the language [...] has to be taken in its global matrix: contextual features as well as social, emotional and even physiological
Host cell targets of bacterial infections: combining systems biology and mechanistic approaches – HostTarget
Identification and characterization of host targets of bacterial infections for the developement of new anti-infective treatments
Deciphering and modifying the rules of epigenetic regulation in chromatin – EPIGENEREG
states as determined from a limited number of key features. In the project proposed here, we set out to develop
The PrPC PDK1 TACE signaling axis at the cross-road of several aggregate-prone protein-associated neurodegenerative diseases – Prpc Pdk1
by distinct etiologies and pathophysiological features. Although each disease displays specific clinical
Predict to prevent frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) – PREV-DEMALS
stage; and no clinical, biological or imaging features can predict the underlying pathology in living
Characterization by Cryogenic Electron Microscopy of Structural Differences in Protein Translation between Eukaryotic Pathogens and Mammals – CryoEM80S
The relative conservation of the ribosome among eukaryotes complicates substantially the search for specific drugs against eukaryotic pathogens such as certain protozoa like plasmodium and kinetoplastids.<br />Our work along with other studies demonstrates the existence of significant structural differences between ribosomes of protozoa and mammals. Using Cryogenic electron microscopy, we endeavor to investigate such structural differences.
Novel treatment strategies for autosomal dominant chronic mucocutaneous candidiasis – EURO-CMC
STAT1 signaling. Furthermore, a characteristic feature of AD-CMC patients is a deficiency in the Thelper
Fast Skeletal Troponin Activation for Restoring Muscle Strength in Mouse Models of Nemaline Myopathy: a Molecular, Cellular, Metabolic and Functional Assessment – TREAT-NEMMYOP
of 1 in 50.000 live births. The main clinical feature of NM is muscle weakness, which impairs swallowing