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Heart-targeting agents for therapeutic delivery in failing cardiomyocytes – CardioTarget
as ~50%. Regardless the causes of HF, a common feature is the persistent activation of the ß-adrenergic/cAMP
Evolution of a kin recognition system in social insects – EVOKIN
9-exon structure. Strikingly, a similar suite of features has recently been observed in Vespid wasps, which
AUTOmated exploration of MATerials for PROton-conducting solid oxide CELLS – AUTOMAT-PROCELLS
properties, stability and structural-chemical features, - the production of exhaustive information (hundreds
Adaptability of the Golgi-dependent secretory routes – GolgiPS
cardiomyocytes and intestinal cells. Several features of Golgi-dependent processes will be analysed
Origins of the Eukaryotic Endomembrane System: did Arf Family GTPase Function Arise in Archaea? – ArchaeArf
predicted proteins possess the hallmark biochemical features of Arf_E GTPases that enable their function. Small
Nanotherapy to modulate the immune response in sepsis – NANOSEPSIS
tory therapeutic strategies in sepsis need to feature two key characteristics: a rapid effect and a high
Understanding the evolution of antimicrobials resistance in environmental vibrios – RESISTE
suggest that antibiotic resistance is a common feature in environmental vibrios and that oysters could
à compléter – CHIRON
the operating environment, the CHIRON project features the unique innovations simultaneously on robotics
Decision Making Under Uncertainty – DEMUR
exceptional event that we are currently experiencing features uncertainty on several dimensions, like the duration
Integrated analysis of the role of transcription factor SF-1/NR5A1 and its dosage-dependent target genes in gonadal function and disorders of sex development (DSD) – Goldilocks
The transcription factor Steroidogenic Factor 1 (SF-1; NR5A1 in the official nomenclature) has a pivotal role in adrenogonadal development. Mutations in NR5A1 account for 10-20% of DSD with known genetic diagnosis. tTght regulation of SF-1 dosage is at the heart of the mechanism how this transcription factor regulates gene expression and perturbations thereof have important pathological consequences.