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TRACE METAL LEGACY on MOUNTAIN AQUATIC ECOGEOCHEMISTRY – TRAM
Following the onset of the industrial revolution and the use of fossil energy, humans can now indisputably be seen as major geological agents. At present, anthropogenic fluxes of up to 62 chemical elements surpass their corresponding natural fluxes. Due to their geological features mountain environments have been exploited since the beginning of metallurgy.
Integrated IR sensor based on SEIRA effect for an efficient detection use of low concentration chemical and biological species – LOUISE
In a context of growing demand for integrated sensors for environmental and biological applications, the objective of the LOUISE project is to design and evaluate a micro-sensor for the implementation of infrared spectroscopy amplified by surface plasmonic effects.
Small islands addressing climate change: towards storylines of risk and adaptation – STORISK
This 48-month project develops an integrated approach to climate-related risks (i.e., coastal erosion, marine inundation and reef mortality) in French overseas territories under climate change. It will generate an innovative transdisciplinary protocol and practice-oriented knowledge, including a didactic<br />explanation of the processes going from hazards to impacts and vulnerability, and the highlighting of the most promising ways to enhance adaptation to climate change.
MS-AFM-IR platform for structural analysis of lipid inclusions in oleaginous micro-organisms – BioSound-IR
several model strains of yeast. Another interesting feature of Streptomyces, a soil-born bacteria, is its natural
Multiscale sequencing of G/C rich repeated genomic DNA via single molecule manipulation in magnetic tweezers – Museq
and the aim of this project is to build on these features to develop an inexpensive, reliable method to
Dynamics of Nuclear Architecture and LIFEspan – DNA-Life
The 3D organization of the genome is an important control mechanism of genomic function.<br /><br />Our recent data unveiled that chromosomes adopt distinct organizations according to the metabolic status of the cell. In particular, long-lived quiescent cells cells group their telomeres into a hypercluster, reshaping the genome architecture into a conformation that may contribute to maintain longevity of<br />quiescent cells (Guidi et al, 2015).
New molecular insights into the regulation of the spatiotemporal program of DNA replication – OriMolMech
overlap between replication origins and a specific feature found genome wide was the association of origins [...] of more open chromatin structure. An attractive feature of this model is its self-reinforcing nature but
Multi-luminescent up-converting nanohybrids with controlled blinking for super-resolution imaging and single particle tracking – BLINK
Crowned by the 2014 Nobel Prize, new non-invasive, far-field super-resolution microscopies classically rely on the excitation of fluorescent probes with a high energy light. The aim of the Blink project is to exploit the “upconversion” phenomenenon, a non linear process that converts near infra red light into visible ones in a non coherent way.
Resistance to thyroid hormone due to TRa1 mutation: an emerging genetic disease. – ThyroMUT2
This rare genetic disease, for which the clinical features are surprisingly variable, was discovered in 2012
THE BILE ACID TGR5 RECEPTOR IN LIVER REGENERATION AND REPAIR – BaTiLiRe
fibrosis. An important, although largely unexplored feature is that after injury and during liver repair, liver