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Statistical mechanics of geometrical and topological metamaterials – METAMAT
whose mechanical response is mainly governed by features other than the base material itself, namely its [...] s/disorder play in their response, when these features are frozen into the structure or allowed to evolve
Outsmarting Beta-lactam resistance in Meningococci and Pneumococci – ORBiMP
with various precursors, to reveal molecular features essential for functionality. These insights will [...] ion than at reacting with drugs. What are the features of the substrate that contribute to maintaining
Characterization by Cryogenic Electron Microscopy of Structural Differences in Protein Translation between Eukaryotic Pathogens and Mammals – CryoEM80S
The relative conservation of the ribosome among eukaryotes complicates substantially the search for specific drugs against eukaryotic pathogens such as certain protozoa like plasmodium and kinetoplastids.<br />Our work along with other studies demonstrates the existence of significant structural differences between ribosomes of protozoa and mammals. Using Cryogenic electron microscopy, we endeavor to investigate such structural differences.
Specificity of secretory IgA and their impact on gut microbiota composition and host immunity. – METAntibody
pathogens, while benefitting from unique and essential features of symbionts. Of note, bacteria acting as symbionts
Effort and coordination in the production of stop consonants – StopNCo
What stop consonants can teach us about the control and coordination of speech gestures
GABA developmental sequence in autism – DevAutism
the deficient chloride regulation is a general feature of autism independently of the mutation by testing [...] oxytocin and autism. The demonstration of common features between delivery, GABA signals, oxytocin, and
LIPA as a promising target to fight cardiometabolic diseases – LIPOCAMD
worldwide. Chronic low-grade inflammation as a common feature in this syndrome has been associated with excess [...] tissue infiltration inflammation resembling to key features of the metabolic syndrome. Hypothesis: LIPA-dependent
deFective Autophagie in Sinusoidal endothelial Cells In Non Alcoholic sTeatohEpatitis Development – FASCINATED
NASH is a frequent and potentially serious disease affecting particularly individuals with a metabolic syndrome. <br />Autophagy in Kupffer cells has an antifibrogenic activity since autophagy invalidation promotes liver fibrosis by regulating hepatic inflammation. Conversely, autophagy in hepatic stellate cells is profibrogenic since it contributes to the activation of hepatic stellate cells and is required for hepatic fibrogenesis. The role of autophagy in LSEC is unkown
Study of the association of microRNA and mitochondria and their role in regulation of neuronal cell death in Fragile X Tremor Ataxia Syndrome (FXTAS) – MITO-FXTAS
Fragile X-associated tremor/ ataxia syndrome (FXTAS) is an inherited neurodegenerative disease. We propose to investigate further the molecular mechanisms, including misregulation of mitochondria in which our partner, Prof Singh is expert, underlying pathogenicity in FXTAS. To achieve this goal, we will develop (1) novel state-of-the-art neuronal cell models based on patient iPS cells, as well as (2) novel animal (transgenic mouse) models of FXTAS.
SuperSUN – a new high-density source for ultracold neutrons – SuperSUN
inelastic scattering in superfluid helium. A novel feature and key component of SuperSUN is a magnetic multipole [...] the magnetic reflector, which is a very welcome feature for such experiments. Modern experiments on short