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Fonctionally relevant conformations of the protein transporter FhaC: probing the lateral opening of a beta barrel in a biological membrane – OPEN_BAR
pertussis. The FHA/FhaC pair is a model TPS system, and FhaC is a recognized Omp85 paradigm. The Omp85 [...] gradient. From a basic-science perspective, how they mediate protein transport is a focus of intense [...] periplasm. A hallmark Omp85 feature is the conserved extracellular loop L6 whose tip interacts with a conserved
Developing a Multi-scale account of Attentional Control as the constraining interface between vision and action: A cross-species investigation of relevant neural circuits in the human and macaque Brain. – MAC-Brain
MAC-Brain proposes a fresh new and systematic approach to the study of the multiple priority signals that guide attention in the primate brain and of their interaction. It is aimed at developing an innovative, integrated theoretical account of Attentional Control in the human and macaque brain, alongside with an effort to make it easily available for translation into a comprehensive computational framework, with the collaboration and in the service of computationally-oriented HBP platforms.
Effect of a shock wave on a structure with contact using mesh refinement and parallelism – PRECIS
elements. The solid is simulated using a Discrete Element method, a Finite Volume method is used for the [...] project is the development and mathematical analysis of a numerical tool for the simulation of the interaction [...] the coupling scheme requires the reconstruction of a fluid/solid interface and the definition of an interface
BMP9 as a major regulator of vascular tone in Pulmonary Arterial Hypertension: a promising new therapeutic target – B9inPAH
project should provide a better understanding of the BMP signaling pathway and a new therapeutic approach [...] Cardiovascular diseases are a major economic burden on health care systems and represent one of the leading [...] that defects in the BMP signaling pathway result in a large number of cardiovascular diseases. Although
Basque in the Making: A Historical Look at a Language Isolate – BIM
annotation, and a rich set of metadata structure. The database will be constructed out of a reference corpus [...] project has two basic goals: the first one is to launch a systematic diachronic study of some of the central [...] the successive attested stages of the language in a number of basic linguistic features, in order to extract
Developing a natural peptide as a novel potent non-opioid analgesic – PeptOPain
administration. In addition, in a mouse model of inflammatory pain, a comparative study has recently shown [...] therapies against chronic pain. Mambalgins represent a real opportunity to develop novel analgesics. These [...] peptides specifically block Acid-Sensing Ion Channels, a set of ion channels emerging as important targets
A multidisciplinary and integrative approach for deciphering the assembly, structure and dynamics of a contractile tail baseplate – T6-PLATFORM
ts. Finally, TssA interactions during T6SS biogenesis will be defined by fusing TssA to the biotin ligase [...] comprise an inner needle (or inner tube) wrapped by a sheath, built on an assembly platform - the baseplate [...] recently reported that the T6SS baseplate docks onto a trans-envelope complex that positions and orients
The Linguistic Crescent: A Multidisciplinary Approach to a Contact Area between Occitan and Oïl Varieties – CROISSANT
Dôme, and South Allier). On a map, this strip of land has the shape of a half-moon, hence its name (first [...] expertise. The aim of this project is to provide a multidisciplinary approach to these now endangered [...] following main lines of research : (1) the building of a multi-dialectal corpus comprising with (i) oral texts