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A Comprehensive Computational/Experimental Analysis of the Hofmeister Effect – Hofmeistgemini
The goal of this project is to carry out complementary experiments and simulations to determine the effect of systematic variation of the counterions and headgroup structures on the properties of cationic amphiphiles to illucidate the forces contributing to ion specific interactions from the molecular level to bulk solution properties of amphiphile aggregates.
A theoretical investigation of the role of the chemical bond in the Raman and fluorescence response of molecule-semiconductor nanoparticle hybrids – FRAMOLSENT
of a molecule chemically bound to a nanoparticle or cluster of a metal oxide that behaves as a semiconductor [...] will undertake a unified treatment of both fluorescence emission and Raman scattering in a nanosystem consisting [...] equation we separate the hybrid into a primary quantum region and a secondary region responsible for e
Construction of a composite surrogate marker of the long-term survival: application to kidney transplantation – CSM (Composite Surrogate Marker)
from the monitoring of a single parameter (i-e graft and patient survival) to a composite marker that [...] and dead recipient with a functional graft. The primary objective is to define a composite variable that [...] an optimal methodology to consider a great number of parameters in a flexible manner. Neuron networks have
A new Fragment-based Approach for inhibition of hk3 and matriptase, two up-regulated serine proteases implicated in tumor progression – FragSPIN
Creation of an experimental pipeline dedicated to the generation of new promising inhibitors of serine protease with therapeutic interest in malignant breast and prostate cancers. The integrated platform combines protease production, parallel inhibitor syntheses and inhibition screening.
Magnetic patterning and mechanically induced differentiation of stem cells. A novel approach towards tissue engineering. – MagStem
The aim is to develop new magnetic cellular patterning approaches in order to explore the effects of organization and externally applied forces on stem cell differentiation, in particular for tissue formation.
Evolutionary dynamics and genetic basis of dominance : sporophytic self-incompatibility in the Brassicaceae as a case study. – BRASSIDOM
genetic phenomenon whereby one of the two alleles at a diploid locus is masked at the phenotypic level, is [...] alleles at other genes, have been postulated by Ronald A. Fisher as early as 1928, but they were never documented [...] controlling self-incompatibility in the Brassicaceae, a trans-acting small RNA acting as dominance modifier
EGFR/ras/NFkB2-STAT3 pathway: a new tool for the targeted therapy in colorectal cancer. – BenCPP2011
Colorectal cancer is a major public health issue as the 2nd cause of cancer-related mortality in Western [...] formulate the hypothesis that successive events reaching a tumor development include the inhibition of cell cycle [...] senescence. This bypass is usually associated with a resistance to anti-tumoral treatments. Furthermore
Bacillus subtilis mRNA metabolism and gene expression : a study on the function and structure of the novel and essential ribonucleases Y and J – RNAJAY
The instability of messenger RNA is fundamental in all organisms and allows to rapidly adjust protein synthesis to environmental changes.Understanding the factors and enzymes involved in RNA degradation is thus important for understanding the control of gene expression
Structural and functional exploration of a novel family of proteins having RNase P activity – PRO-RNase P
Structural and functional study of a novel kind of RNase P composed of a single protein in Arabidopsis.
The Orange Carotenoid Protein : a photoactive protein involved in photoprotection in cyanobacteria – CYANOPROTECT
CYANOPROTECT: Study of a cyanobacterial photoprotection mechanism involving the Orange Carotenoid protein, a new photoactive carotenoid protein