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Development of a Nested Association Mapping population for complex traits dissection in Brassica napus – BrassiNAM
The cultivated surface kept growing since 2003 as a consequence of the development of non-food uses of [...] s/sustainable agriculture During the last years a technological breakthrough was observed in the domain [...] of plant association genetics pioneered the use of a new type of association populations, designed to
Preclinical analysis of the efficacy of a LIM Kinase inhibitory compound for primary and metastatic cancer chemotherapy – LIMINIB
promising, showing a good therapeutic efficacy together with a good tolerance. A study, which aims to [...] ed that the level of cofilin activity, a protein that plays a central role in actin microfilaments dynamics [...] last step of a cascade that regulates actin dynamics. It has been shown that LIMK plays a central role
Preparation and in vivo analysis of “mCD4-HS12”, a synthetic glyco-conjugate which inhibits HIV entry. – HEPACLAMP
undergoes a conformational change that exposes a second binding site, then recognized by a coreceptor [...] developed a new molecule that enables us to reach this objective. This compound, mCD4-HS12, comprises a small [...] by three patents (WO03089000, WO2008015273A1 and WO2009098147A2). The purpose of the present program
Development of a new platform of vectorization of biologically active molecules: application to antigen/adjuvant delivery to dendritic cells for vaccination – OPTIVAC
molecules for their selective delivery to target cells is a major objective since this strategy allows potentiating [...] plasmacytoid subsets, identified both in mice and humans. A large body of data shows that the level of adaptive [...] targeting through specific surface markers, represents a critical way for the development of preventative and/or
High yield production of monodisperse capsules suspension by continuous droplet interface crossing encapsulation (cDICE) controlled by a centrifugal force – cDICE
microns with a small polydispersity, i.e. a standard deviation to mean ratio less than 10%. A patent application [...] the projet is to complete the proof of concept of a new process for the production of capsules of various [...] composition of the shell. The production of capsules is a exploding field where the global needs are huge, but
Targeting of the Tn antigen by a specific chimeric monoclonal antibody in ovarian cancer immunotherapy – ANTITN
cancers, and is thus a good candidate for antibody-mediated cancer immunotherapy. In a preliminary study [...] models of ovarian cancer, which is a necessary step before starting a clinical development phase. We will [...] conjugated to a cytotoxic drug. This development phase will be performed in collaboration with a private
Creation and Aluminium. From the discovery of an industrial material to its positioning as a heritage object: Invention, innovation, markets, 19th-21st century – CREALU
“creation” of a material, its industry and uses. Indeed, aluminium may be considered as a « laboratory [...] ons by users and consumers. A multidisciplinary approach will allow a new comprehension of the factors [...] midth of the 19th century. If aluminium, which was a creation of Science, has succeeded to become the most
The Book : a Space of Creation (XIXth-XXIth Centuries) – LEC
The book : a Space of Creation (XIXth-XXIth Centuries) This proposal contains a programme of research [...] engaged in a relationship of accompaniment, conjunction or disjunction, which goes well beyond a relationship [...] , etc.) as well as on books where the text is in a dialogue with the visual image. Thus it will study
Processes of creation and formation of a scientific language: about medieval French – Crealscience
focused on medieval French which seems a nodal point, unite a research about dictionary to make obvious [...] The beginning of a French scientific language before Modern times – and especially in the middle Ages [...] this field and because of the difficulty to have a panoramic view of the terminological creation in this