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Surface and volume modulation of fast deforming cells and organelles – SurVol
Cells are often described as almost spherical objects. However, the dense environment of the tissues keeps them away from this simple shape. Cells can undergo rapid deformation as they migrate through dense tissue and as they move through blood capillaries. In this project, we propose to study the large deformations of cells, the associated responses and their importance for the migration of immune cells.
Sublingual Vaccination by polysaccharide-based patch – BuccaVac
Mucosal administration, and in particular sublingual administration, of vaccines allows the induction of both systemic and mucosal immunity. However, liquid administration leads to a dilution of the vaccine in the saliva. BuccaVac proposes the development of a sublingual patch for the induction of a strong immunity against flu virus by induction of a local response in the upper and lower respiratory tract, providing a strong protection directly at the portal of entry of the virus.
Structural Mass Spectrometry to study the interplay between proteasome complexes regulation mechanisms – ProteasoRegMS
The proteasome is an essential multi-enzymatic complex responsible for the correct recycling of proteins that could be deleterious to the cell. Its proteolytic activity is thus tightly regulated by different mechanisms. In this project we aim at better understanding the interplay between these mechanisms, using innovative Mass Spectrometry approaches and in the context of Irritable Bowel Diseases.
Stone-age memory in a modern world: Further evidence from contamination effects – SAM
According to the adaptive memory view, our ability to remember is likely suited to solving problems related to fitness (reproductive value), especially those that were important in the ancestral environments in which human memory evolved. A contamination effect in memory has recently been demonstrated and it supports such a conception of human memory.
Stabilization process in marine surface robotics inspired by swimming snakes – SSSNAEQ
A new generation of robots inspired by the swimming of aquatic snakes has recently emerged in academic contexts. Thanks to their exceptional manoeuvrability, they could intervene urgently in complex situations. However, despite this potential, their surface stability is too precarious. The SSSNAEQ project aims to remove the scientific barriers to surface instability by taking inspiration from snakes,
Smart Autonomous Microscopy – SAMic
Our goal is to automate disturbance microscopy experiments for non-expert microscopy users and HCS applications.
Role of solid asperties on dry foam flows – AsperFoam
relevant in many applications. By the end of this ANR, we will be in position to provide clear and robust [...] designing surfaces used in foam rheology. This JCJC ANR will reinforce the position of the applicant to be
Role of Sting in lymphocyte development and function – LYMPHO-STING
STING drives type I interferon (IFN) and inflammatory responses. Patients with STING gain of function (GOF) mutations develop an autoinflammatory disease (SAVI). We reported a new mouse model of STING GOF, with severe type I IFN-independent combined immune deficient (SCID) phenotype, affecting all lymphoid lineages, with lymphoid functional defects partly described in SAVI patients. We propose to characterize the mechanisms underlying the new role of STING in lymphoid development and function.
Regulatory networks governing craniofacial muscle diversity – MyoHead
Craniofacial malformations are among the most common human birth defects and have multiple etiologies that affect diverse tissues. The underlying genetic, developmental and clinical causes of these malformations are largely unknown. Therefore we aim to identify all of the cell types that give rise to craniofacial structures and the molecular regulators that lead to the establishment and morphogenesis of the various cell lineages in the head.
ROLE OF CAVEOLIN IN B CELL DIFFERENTIATION AND PLASMA CELL FUNCTIONS – sCAV-BandPC
several expectations of the challenges set by the ANR, will bring a sum of original facts that will benefit