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Data and Prior, Machine Learning and Control – DeLiCio
We propose to combine machine learning and control theory for sequential decision-making of multiple agents. The project proposes fundamental contributions: adding stability to the algorithms of reinforcement learning; data driven methods for robust control; hybrid ML / CT methods for multi-horizon control and planning; decentralized control. The methodological contributions of this fundamental IA project will be applied to the robust control of UAV fleets
Analysis of SNARE-mediated regulation of plasma cell biology – PC-SEC
Plasma cells and the antibodies they secrete are essential for protective immune responses. However, they can also contribute to the pathology of numerous diseases. Despite their relevance in health and disease, the mechanisms underlying antibody secretion are still poorly understood. This is an essential question as a better characterization of the involved molecular actors may pave the way to improved antibody production, and to the development of new therapies for antibody-driven diseases.
Transformations to Groundwater Sustainability : joint learnings from human-groundwater interactions – T2GS
Billions of people around the world rely for their everyday existence on groundwater. Its invisibility, however, makes groundwater notoriously difficult to govern, also complicating efforts to avoid depletion or pollution. There is an urgent need to creative insights about ways of dealing with the intrinsic tensions that characterize groundwater governance: between individual and collective interests and between short-term gains and longer-term sustainability.
Rainfall Wind Turbine or Turbulence – RW-Turb
RW-Turb relies on the expertise of HM&Co in measurement and modelling across wide range of spatio-temporal scales of atmospheric turbulence and rainfall to quantify the impact of the latter on wind power production. <br />This project benefits from an industrial partnership with Boralex, a wind power producer.<br />RW-Turb will open new paths to improve nowcasts of power production, a major challenge in a framework of increasing use of renewable energies in France and Europe.
Structural dynamics of a dimeric GPCR at the single molecule level – DynaMuR2
Our project aims to understand the conformational dynamics of a receptor that is part of the major drug targets.
Temporally Heterodyned Theta Tomographic Microscopy – THTTM
THTTM Project aims at characterizing moving samples using Tomographic Diffraction Microscopy (TDM). These aspects will be studied through two main axes:<br /><br />- discrimination of static/dynamic areas of a sample using laser Doppler 3D imaging<br />- Moving object characterization using TDM
Role of Tbx3 in directing the functional identity of POMC neurons in obesity – neuroIDobese
Chronic consumption of hypercaloric diets may trigger a ‘neuronal identity crisis’ in certain subpopulations of hypothalamic neurons due to the impaired action of the T-box gene 3 (Tbx3), a transcription factor that maintains hypothalamic neurons identity during postnatal life. Such a loss of identity may undermine the working machinery of POMC neurons, ultimately leading to obesity and its associated metabolic complications, albeit this hypothesis has yet to be investigated.
Microscopie electronique en transmission sur le plateau Palaiseau Orsay Saclay
modes de phonons (2021), luminescence de perovskytes nanométriques (2021) [...] d’énergie sur prototype (avril 2018) et sur CHROMATEM (2021) - EELS à 10 meV de [...] stades de croissance de nanofils de GaAs sur Si (2021) NANOTEM
Stone-age memory in a modern world: Further evidence from contamination effects – SAM
According to the adaptive memory view, our ability to remember is likely suited to solving problems related to fitness (reproductive value), especially those that were important in the ancestral environments in which human memory evolved. A contamination effect in memory has recently been demonstrated and it supports such a conception of human memory.
Role of Piezo1/KCNN4 interaction in red blood cell physiopathology – ROPKIP
Activation of the mechanosensitive channel PIEZO1 in the red blood cell (RBC) membrane induces a calcium influx responsible for the activation of a KCNN4 potassium channel. The functional coupling between these two ion channels leads to a leak of K, Cl and water and therefore dehydration of the RBCs. Independent mutations on either of these ion channels lead to erythrocyte dehydration responsible for the rare hemolytic anemia, hereditary dehydrated stomatocytosis.