Aerosol-assisted synthesis of spherical mesoporous CeO2 parTicles as smart nAnoCarriers for theranosTIC – TACTIC
Nowadays, we are faced with the issue that conventional drug delivery systems must be administered systematically in high doses and tend to cause severe side-effects because of the nonspecific uptake of drugs by healthy tissues/organs. In this work, an easily controllable aerosol-based approach is proposed to produce biocompatible, mesoporous cerium oxide particle with well-controlled internal morphology and shell porosity for controlling the drug loading and release properties. Moreover, in order to have a specific release we will chemically modify these particles with modified polysaccharides (elaboration of stimuli-responsive systems). The ultimate goal of our project is to propose a theranostic platform capable of assessing diseased cells and able to deliver therapeutic molecules in a controllable way.
Project coordination
Sabrina Belbekhouche (Institut de Chimie et des Matériaux Paris-Est)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partner
ICMPE Institut de Chimie et des Matériaux Paris-Est
Institute of Particle Technology
INSERM -UMR 1151 Institut National de la Santé et de la recherche Médicale
Help of the ANR 578,460 euros
Beginning and duration of the scientific project:
- 36 Months