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Inferring a brain model based based on multi-protocol functional neuroimaging data. – BrainPedia
BrainPedia introduces a new paradigm, in which statistical analysis of functional brain data is now embedded in a knowledge system that accumulates and organizes experimental evidence to refine a persistent brain model. The final purpose of the project being to provide neuroscientists with a useful tool for spatial modeling.<br />
Deciphering LGI1-related epilepsy using conditional knockouts – LGI1 KO
Mutations of LGI1, which encodes a protein of unknown function, is the cause a familial form of epilepsy. The study of genetically-modified mice reproducing the genetic disease and the phenotype of spontaneous seizures, will guide us toward the comprehension of underlying mechanisms of this disorder.
Presubicular head direction cells - cellular properties and synaptic connectivity – Head direction
The presubicular cortex is part of a neuronal circuit coding for spatial information. We dissect the neuro-anatomy and physiology of this small network: we examine how specific cellular currents and firing patterns of presubicular neurons contribute to its functional role, and how inhibitory and excitatory synaptic connections are organized.
Plastid/nucleus interactions during plant development – IPNODEV
The goal of this project is to investigate cellular mechanisms involved in the control of chloroplast division by the nucleus and reciprocally in the regulation of cell proliferation and differentiation by chloroplast-derived signals.
CHromatin and ROS: Role of Topoisomerase VI-mediated chromatin remodelling in the transcriptional response of plants to singlet oxygen, ROS and abiotic stresses. – CHROS
Molecular mechanisms of plant response and acclimation to environmental stresses. Role of chromatin remodeling factors in the transcriptional response of plants to oxidative and abiotic stresses.
Characterization of the sister chromatid cohesion step of the E. coli cell cycle – SISTERS
In bacteria, chromosome segregation begins before the end of replication. Imaging of the chromosome by fluorescent microscopy revealed nevertheless a step between replication and segregation of any locus. This step is called cohesion. We have developed a genetic tool allowing by mesuring the recombination between sister chromatid to study the molecular mechanisms involved in sister chromatid cohesion.
DNA polymerases and damaged nucleic acids in archaea: Genome maintenance and Biotechnology – ARCHPOL
Isolation and characterisation of thermostable DNA polymerases in the presence of DNA lesions in the hyperthermophilic archaeon, P. abyssi. Examination of conventional and non conventional mechanisms in the genome maintenance of microorganisms inhabiting extreme environments.
Novel functions of Transferrin receptor: A multi-ligand receptor implicated in health and disease – TFRIGA
in which the injection of IgA complexes induce features of IgAN. Similar to erythropoiesis, IgA1-IC increased
Function of cytoplasmic dynein in mitochondrial maintenance – DyneMit
gene showed abnormalities in the striatum and features of diabetes. This was associated with a widespread