Analyse intégrée de la résistance dans les cancers hématologiques

The Valitutti team has developed a new approach for instance segmentation in microscopy that takes advantage of the highly innovative application of Cartesian genetic programming (CGP) to biomedical images. The Laurent team has started the MAGALY Program: Mapping of T cells and vasculature in lymphoma: a single cell study for localization and functional characterization of T lymphocytes infiltrating human lymphomas. The Meggetto/Pyronnet team has obtained a compilation of "Omics" dataset revealing downregulation of five key genes in crizotinib-resistant ALK+ anaplastic large cell lymphoma samples. The Segui/Andrieu team took advantage of their two clinical trials in advanced melanoma patients treated with immune checkpoint inhibitors to identify a glycosphingolipid signature in plasma that predicts the resistance to the combination of ipilimumab and nivolumab. The Girard team investigated the mechanisms by which anti-CTLA-4 antibodies modulate tumor-associated high endothelial venules TA-HEVs), specialized blood vessels for lymphocyte entry into tumors. The Guillermet-Guibert team hypothesized that the expression and activity of PI3K enzymes participate to mitochondrial and metabolic adaptation during tumour development and treatment. Ayyoub/Devaud team : showed that enterotropic α4β7 integrin-expressing CD8⁺ T cells, that recognize tumor antigens, have the potential to emigrate the colon and to accumulate in extra-intestinal metastases, including hepatic tumors. The Calvayrac team conducted the LUNG-RESIST clinical trial to monitor and characterize response to TT in EGFR-mutant NSCLC patients using liquid biopsies. The Martinet team reported bioinformatics analyses, revealing significant alterations in the NK cell populations of multiple myeloma (MM) patients. The Sarry team identified leukemic heme/porphyrin and iron-sulfur cluster biosynthesis as targetable and critical pathways of drug-tolerant residual disease (AML).