Centres d'excellences Laboratoires d'excellence

Développement de stratégies innovantes pour une approche transdisciplinaire de la maladie d'Alzheime


Mots-clés : Alzheimer's disease and related disorders; Transdisciplinary research; Genomics; Cellular and Animal models; Social and Healthcare Research; Ethics; Diagnosis-Prognosis; Biomarkers and Drugable Targets; Clinical Trials; Personalized Medicine.


In 2020, due to the COVID19 pandemic and to the lockdowns, the activities of the 8 DISTALZ teams have been halted between the mid-March and the end of June. This situation has also postponed the setting up of the new budgets 2020 and 2021. In 2020, we entered a new 5-year contract with Universities and some teams evolved thanks to Distalz momentum


Its cutting edge research programme has positioned DISTALZ as a key partner of the structuration, attractiveness and the national and international visibility of the Lille I-site ULNE and Nice Idex UCA JEDI research strategies. DISTALZ coordinates several European and global consortia, in genomics in particular, and chairs the Joint Programming Initiative for Neurodegenerative Diseases (JPND) that brings together 30 countries to more efficiently tackle these diseases. Due to the pandemic, the creation of the new scientific advisory board has been postponed. Among its major publications in 2020: Tau accumulation in astrocytes of the dentate gyrus and neuronal dysfunction and memory deficits in Alzheimer's disease (Nat Neurosci. 2020;23:1567), modelling awareness in Alzheimer's Disease (Journal of Alzheimer's Disease, 76:89) ; does amnesia specifically predict Alzheimer's pathology? A neuropathological study (Neurobiol Aging. 2020; 95:123).


DISTALZ is actively committed to education and training at local, national and international levels with, for instance, its major role in the creation of a graduate school in the precision health of the I-site ULNE that will be launched in 2021. DISTALZ established partnerships with three SMEs (Genoscreen, Alzprotect and SPQI) and major international groups. DISTALZ researchers have filed 3 new patent in 2020. DISTALZ has allowed the success of Lille's bid to host the 13th edition of the International Conference on Frontotemporal Dementias (ICFTD-2022) for Oct 2022. Finally, DISTALZ is involved in the public dissemination of research progress and of the destigmatisation of dementia.


L'auteur de ce résumé est le coordinateur du projet, qui est responsable du contenu de ce résumé. L'ANR décline par conséquent toute responsabilité quant à son contenu.

Informations générales

Acronyme projet : DISTALZ
Référence projet : 11-LABX-0009
Région du projet : Hauts de France
Discipline : 5 - Bio Med
Aide PIA : 16 752 475 €
Début projet : février 2012
Fin projet : décembre 2024

Coordinateur du projet : Philippe AMOUYEL
Email : philippe.amouyel@pasteur-lille.fr

Consortium du projet

Etablissement coordinateur : Fondation I-SITE Université Lille Nord-Europe
Partenaire(s) : COMUE Lille Nord de France, Institut Pasteur Lille, CNRS Côte d'Azur (Valbonne), AP-HP, CHU de Lille, INSERM Délégation Provence-Alpes-Côte d'Azur et Corse, INSERM Délégation Nord Ouest, CNRS Hauts-de-France, Université d'Artois, Université de Lille, Université Paris-Saclay, Université Côte d'Azur

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