imaging; super-resolution fluorescence microscopy; high-content analysis; electron microscopy

Plateau de microscopie de criblage à haut débit et d'analyse à très haute résolution

Equipements d'excellence (EQPX)

Equipements d'excellence

Informations générales

Référence projet : 10-EQPX-0004
Etablissement Coordinateur : COMUE Lille Nord de France
Région du projet : Hauts de France
Discipline : 5 - Bio Med

Aide de l'ANR 6 794 820 euros
Investissement couvrant la période de février 2011 à décembre 2019

Résumé de soumission

The ImagInEx Biomed project has been ranked in first row of the first PIA call. The ImagInEx Biomed project proposes to establish a pipeline from the High-throughput imaging to the very-high content analysis. This includes (i) electron microscopy, both transmission (TEM) and scanning electron (SEM) microscopy with cryo and volume analysis option, and with chemical signature characterization (TEM), (ii) flow imaging and (iii) atomic force microscopy coupled to super-resolution microscopy. All the instruments have been installed at the end of the scheduled of the phase I (investment).

The project in its phase II (running) supports research activities in several field: infection-immunity, metabolic diseases (cardiovascular disorders and diabetes), cancer, and neurodegenerative diseases. Among the major released work, can be mentioned: identification of the adhesive receptor of N meningitidis, characterization of a new type of medicament against tuberculosis, characterization of the membrane trafficking of parasites into the host cell and of the bacteria hijacking of the autophagy pathway, development of technological methods on correlative microscopy.

The ImagInEx Biomed project has also launched meetings, involvement in technological networks and international workshops, and has acquired through the Imaging Facility a real renowned visibility. 

L'auteur de ce résumé est le coordinateur du projet, qui est responsable du contenu de ce résumé. L'ANR décline par conséquent toute responsabilité quant à son contenu.

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