Référence projet : 10-COHO-0001
RST : Bénédicte STENGEL
Etablissement Coordinateur : Université de Paris XI (Paris Sud Orsay)
Région du projet : Île-de-France
Discipline : 5 - Bio Med
Aide de l'ANR 5 861 580 euros
Investissement couvrant la période de février 2011 à décembre 2024
The overall objective of the CKD-REIN cohort study is to develop a research platform to address key questions regarding the determinants and biomarkers associated with CKD outcomes and to assess clinical practices and health care organization in CKD.
CKD-REIN is a prospective cohort study carried out in 40 nephrology outpatient facilities, nationally representative with respect to geography and legal status: public, private non-for-profit, and private non-for-profit. From July 2013 through March 2016, a total of 3033 patients were included during a routine nephrology visit. The five-year follow-up phase started in July 2014. As of March 23, 2017, the first year of follow-up is almost completed, the second year is well advanced and the third year has started.
Fasting blood (40 mL) and second morning urine (40 mL) samples were collected by nurses in 2720 participants at enrolment. These samples are also being collected as part of the on-going 2-year follow-up in a subsample of 1,200 patients.
Finalization of the inclusion phase in April 2016 enabled to launch a number of studies using baseline data. Their results were presented at several national and international meetings and are the subjects of papers in progress. The choice of first research topics was guided by the willingness to show an overview of the study population and to address major CKD-related issues, and innovative or hot topics such as practice patterns of anti-diabetic therapy in patients with declining kidney function, current status of care regarding recommendations for the prevention of CKD progression, specific aspects of CKD and CVD care in the elderly, adequacy of drug prescription in patients with declining kidney function, etc
Furthermore, proposals on scientific research projects using biological samples have been developped by the CKD REIN partners. The pilot phase of one of these projects, Gut microbiota and outcomes in patients with chronic kidney disease, started at the end of the year.
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