Projets financés

Regenerative therapies require large quantities of functional cellular equivalents to restore or repair injured or diseased native tissues. For example, replenishment of the cardiomyocyte (CM) pool following heart failure requires ~ 109 cells. Synthetic materials in bioreactors provide unparalleled

Inflammatory Bowel Diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by chronic inflammation of the gastrointestinal (GI) tract. Currently available medications, namely small molecular drugs and monoclonal antibodies, present poor therapeutic efficacy and pr

High grade gliomas (HGG) remain incurable despite an incredible number of innovations translated at the bedside in recent years, hence are a major health concern in the EU. We need new technologies for local deciphering of tumour heterogeneity and of the peritumoral uncharted microenvironment that w

Cardiac diseases are the leading cause of death worldwide. Restoring the damaged heart tissue remains an unmet clinical need, and new treatments are needed to recover the injured myocardium. Extracellular vesicles (EVs) have shown potential for cardiac repair. However, low retention and stability af

The project has the ambitious objective of shaping a new therapeutic paradigm for the treatment of idiopathic pulmonary fibrosis through an innovative therapy aimed at reactivating the mitochondrial function of lung epithelial cells using levothyroxine nanoparticles in the form of dry powder for inh

Head and neck squamous cell carcinomas (HNSCC) have a high prevalence and lethality, mainly due to: i) their late diagnosis, ii) the low availability of therapeutic alternatives for HNSCC patients and iii) the acquisition of resistance to conventional therapies.The membrane receptor TSPAN1 is an onc

The effectiveness of chemotherapy is still required to be improved by combating new pharmacological targets and overcoming multidrug resistance (MDR). New nano-scale drug delivery systems can increase the efficiency of anticancer drugs and fight against MDR. Macrocyclic molecules such as dynarene an

The NanoArt project targets heart failure (HF), a major healthcare challenge with significant economic impact, costing the EU approximately €29 billion annually. HF often results from myocardial infarction, where blocked arteries lead to substantial cardiomyocyte (CM) death. Adult CMs have limited r

Colorectal cancer (CRC) is the 2nd leading cause of cancer death, claiming the lives of about 250.000 Europeans annually. CRC patients could greatly benefit from cell-based immunotherapy: dendritic cells (DC) or cytolytic cells. Herein, immune cells are endowed with therapeutic response programs to

Inherited ichthyoses are rare genetic diseases (prevalence 13.3 per million in Europe) that occur at birth or early infancy, causing abnormal scaling, skin thickening, dryness, itching and pain. Despite strong genetic heterogeneity, about half of the patients, particularly those with Autosomal Reces