Projets financés

Early Parkinson's disease (PD) is characterized by propagation of alpha-synuclein inclusion and neuronal loss in many brain regions including small brainstem nuclei, such as substantia nigra and locus coeruleus, and hypothalamic nuclei regulating sleep, later leading to dysfunction of the striatum a

Abnormalities in lysosomes and mitochondria, pivotal organelles regulating cellular homeostasis, are emerging as hallmark features in the pathogenesis of devastating neurodegenerative diseases (NDs) such as Parkinson's disease (PD) and Alzheimer's disease (AD). However, the precise cell-type specifi

The intestinal epithelial barrier (IEB), which primarily consists of epithelial cells stitched together with connecting proteins called tight junctions plays a critical role in health and disease. It acts as a selectively permeable barrier regulating the absorption of nutrients, electrolytes and wat

Alzheimer’s disease (AD) is the main cause of dementia in the aging population affecting disproportionately more women than men (2:1). However, the cellular, molecular and pathogenic mechanisms underlying sex differences in the risk and progression of AD are still unknown, despite the fact that they