Projets financés

In this translational research project involving (i) two rodent models of stress resilience and (ii) existing human cohorts that were previously characterized regarding stress resilience in an ongoing longitudinal study, we will assess the hypothesis that a pharmacological intervention with the keto

The overarching goal of this translational project is to investigate the neurobehavioral responses to rewards and to acute stress as key neurobiological mechanisms underlying individual differences in the risk of developing depressive symptoms at different ages (young and older adults) after early l

Prenatal stress (PS), i.e. maternal stress during pregnancy, is associated with an increased risk to develop psychopathologies. In particular we have recently documented in a rodent model that PS leads to PTSD-like memory deficits in only a subset of mice, highlighting the suitability of this model

Alcohol addiction is a common psychiatric disorder with largely unmet treatment needs. While low to moderate levels of consumption already exert detrimental health effects, there is a large variability of responses to alcohol drinking in the population. We argue that a large proportion of the variab

The lifetime prevalence (~20%) and economic burden ($350 billion annually) associated with major depressive disorders (MDD) make them one of the most common and debilitating psychiatric illnesses. Currently, the diagnosis of MDD and suicidal behaviors are subjective and quantitative biomarkers for

Childhood adversities have long-lasting consequences in terms of mental health and well-being, and, exposure to childhood adversities (Juvenile stress [JS]) significantly increases vulnerability to mood and anxiety disorders later in life. Yet, not all show an increased risk of adulthood psychopatho