Projets financés

In the last century, life expectancy in Europe has increased from 44 in 1900 to 80 years in 2020. However, people are living longer but experiencing more years in ill health, with an increase in age-related neurodegenerative diseases. Lifestyle changes have also contributed to a rise in obesity, whi

a-Synuclein pathology is inextricably linked to the pathogenesis of Parkinson’s disease (PD), yet we have very limited understanding why specific neuronal populations are vulnerable to a-Syn-related PD pathology while others are much more resistant. Likewise, we have very limited knowledge of whethe

Aggregation of the protein alpha-synuclein in neurons and oligodendrocytes in the brain causes a group of neurodegenerative diseases collectively referred to as synucleinopathies, including, among others, Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). I

Aging is a major risk factor for cognitive decline and increases the vulnerability of the brain to neurodegenerative diseases, such as Alzheimer’s disease (AD) which, in turn, dramatically accelerates cognitive deterioration and increases the risk for dementia. The biological pathways linking aging

Alzheimer's disease (AD) has an important genetic component and among the genetic factors characterized, the PLCG2 gene is of major therapeutic interest, because it harbors a reported protective variant with a hypermorphic effect on enzyme function. The pathways and interaction partners of this gene

Multiomics and Big data integration can decipher the mode of action of drugs and possibly identify novel druggable targets as well as diagnostic or theragnostic-associated biomarkers. Alzheimer’s disease (AD) is characterized by complex neuropathological processes driven by amyloid deposition, neuro

Spinal Muscular Atrophy (SMA) is an autosomal recessive neuromuscular disease, which affects motoneurons. Children affected with SMA present difficulties in crawling, walking, breathing and swallowing. SMA is caused by bi-allelic mutations in the SMN1 gene, which encodes the protein Survival of Moto