Projets financés

Chronic neuropathic pain, affecting both central and peripheral nervous systems, is highly prevalent and debilitating, impacting up to 8% of the general population and 25% of chronic pain patients. Despite extensive research over the past two decades, effective management options remain limited, wit

Persistent fatigue (PF) is a highly prevalent transdiagnostic symptom across countries and cultures, and an important cause of disability and reduced quality of life. Acute infection is a common trigger of PF, as exemplified by the ‘Long COVID’ phenomenon. Despite substantial burden for the sufferin

Chronic pain often accompanies neuropsychiatric conditions, impacting patient well-being, and worsening prognosis. The gut-brain axis, autonomic nervous systema and alterations in cortical brain areas have emerged as crucial in pain chronification. Studies in rodents and humans reveal significant ne

Organ-specific autoimmunity is typically associated with adaptive immune responses targeting self-antigens, yet the triggers and cause of these conditions remain poorly understood. This proposal posits that autoimmune encephalitis (AIE) serves as an ideal model for exploring immune-environment inter

Perinatal asphyxia (PA) is a significant contributor to neonatal morbidity and mortality globally. Even brief periods of hypoxia during birth can lead to subtle cognitive impairments and developmental delays, with consequences including difficulties in attention, memory, language, social, and motor

This study investigates the mechanisms underlying susceptibility and resilience to anxiety disorders induced by stress dysregulation of the brain-gut-microbiota axis. Anxiety disorders affect 10-33% of adults at some time in their lives, posing significant public health concerns. The study focuses o

Behavioral responses are based on a continuous bidirectional communication between the body and the central nervous system (CNS). The choroid plexus (CP), a specialized epithelial-endothelial tissue in the brain, provides an interface between the blood and the CNS. It functions as the blood-cerebros

Eating disorders are neuropsychiatric conditions characterized by severe and persistent disturbance in eating behaviors and associated distressing thoughts and emotions. Despite their individual and socioeconomic burden, the etiology of eating disorders is still poorly understood and suitable interv

The Global Burden of Disease Study (2015) highlighted the significant and growing impact of mental disorders on global disability, with depressive disorders ranking as the third leading cause of years lived with disability. Although various treatments are available, it is clear that antidepressant d