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High-throughput technology for detection of RNA modifications
High-throughput technology for detection of RNA modifications
K8/F508del-CFTR, a new target for corrector therapy in cystic fibrosis
life, ubiquitination status, proteolysis and maturation. The second objective is to optimize the efficacy
Dynamic Targeting of Proteins to the Lipid Droplet Surface
To understand the dynamics of lipid droplets, it is necessary first to describe the unique properties of the LD surface, and how proteins associate with and modify this surface. What are the lipid packing properties of the LD phospholipid monolayer compared to a bilayer membrane? Are amphipathic helix-containing LD-associated proteins recruited to the phospholipid monolayer by direct protein-lipid interactions? The goal of the current proposal is to address these questions.
Collective lymphocyte migration
disease, we will first investigate in vitro which maturation stages and environmental settings condition the
Viral RNA enriched exosomes are mediators of the interferon response
Our project aims at defining this newly discovered aspect of the innate immune response triggered by cell-to-cell contacts between virally infected cells and cells specialized for the antiviral response. In particular, we determine the importance of the cell contacts, the carrier of the transmission, the viral and cellular determinants and the induction pathway.
Functional analysis of tubulin detyrosination.
Detyrosination was the first tubulin posttranslational modification to be discovered more than 40 years ago. However, until now the enzyme involved in the generation of this modification, which has been named tubulin carboxypeptidase, remains unknown. High levels of detyrosination are found in neurons and cilia but the function of this modification remains largely unknown because the modifying enzyme has not yet been identified.
Membrane-bound RNase E: role in RNA processing, RNA surveillance and mRNA degradation
Over the past decade, fluorescence microscopy of live cells has challenged the belief that machineries involved in transcription, translation and RNA processing co-localize in the bacterial cell. RNase E, an essential endo-ribonuclease, has recently been shown to be localized to the cell periphery strongly suggesting that key steps in the maturation of transfer and ribosomal RNA and the degradation of mRNA are initiated on the inner cytoplasmic membrane.
Dynamics and mechanics of integrins and regulators organization and interactions at the nanoscale in adhesion sites.
Cell adhesion to the extracellular matrix (ECM) relay force transmission and sensing essential for cell migration, proliferation and differentiation. Integrins constitute the core of adhesion sites (AS), integrating biochemical and biomechanical signals from the ECM and the actin cytoskeleton. AS constitute a complex network of components and binding interactions. The next challenge is to understand the spatiotemporal orchestration of these interactions and their mechanical responses.
Expression of the chloroplast genome: OPR proteins and ribonucleoprotein complexes.
1.5 billion years ago, endosymbiosis of a cyanobacterial ancestor generated a chloroplast. This project aims at an understanding of the network of nuclear genes that control chloroplast gene expression at the post-translational level.
Giant REsonant non-LINearities in Quantum cascade lasers
ion of the QCL emission to the technologically mature near infrared range for sensitive THz detection
