components. Its goal is to increase the technological maturity of the results obtained during the ASTRID OSeP
Our project aims at defining this newly discovered aspect of the innate immune response triggered by cell-to-cell contacts between virally infected cells and cells specialized for the antiviral response. In particular, we determine the importance of the cell contacts, the carrier of the transmission, the viral and cellular determinants and the induction pathway.
Detyrosination was the first tubulin posttranslational modification to be discovered more than 40 years ago. However, until now the enzyme involved in the generation of this modification, which has been named tubulin carboxypeptidase, remains unknown. High levels of detyrosination are found in neurons and cilia but the function of this modification remains largely unknown because the modifying enzyme has not yet been identified.
High-throughput technology for detection of RNA modifications
life, ubiquitination status, proteolysis and maturation. The second objective is to optimize the efficacy
To understand the dynamics of lipid droplets, it is necessary first to describe the unique properties of the LD surface, and how proteins associate with and modify this surface. What are the lipid packing properties of the LD phospholipid monolayer compared to a bilayer membrane? Are amphipathic helix-containing LD-associated proteins recruited to the phospholipid monolayer by direct protein-lipid interactions? The goal of the current proposal is to address these questions.
disease, we will first investigate in vitro which maturation stages and environmental settings condition the
Les changements environnementaux et leurs catégories d’analyse
Most of the industrial countries are experiencing challenges regarding control of peak power consumption and renewable energy development. In view of these constraints, thermal electricity storage systems benefit from having a higher energy density than the PSH and CAES and from limited geological and geographical constraints.
Deciphering the sorting mechanism of GAGs by chemical synthesis of effectors of glycosaminyltransferases – GAG-Sorting
Proteoglycans are a family of complex macromolecules involved in a plethora of natural biological processes but also in the pathogenesis of several diseases including arthropathies, Alzheimer’s disease and cancer. <br />We propose to synthesize new molecules in order to better understand the enzymes and particularly the glycosaminyltransferases involved in the biosynthesis of proteoglycans.