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Tropomyosins and differentiation of actin filament networks – TropActin
dynamics, etc. Experiments will be performed in vitro, on purified and fluorescently labelled proteins [...] (Institut de Biologie Paris Seine) who will perform in vivo experiments on his model system, C. elegans embryo [...] collaborations will support results obtained in vitro and, together, will bring a comprehensive understanding
Towards a comprehension of transferrin protective effects to its therapeutic application in retinal degeneration – Transfiron
Screen for the optimal Tf neuroprotective effect in vitro: The influence of post-translational Tf modifications [...] on its neuroprotective effect will be studied in vitro according to molecular and biochemical tools. [...] and biodisponibility on relevant animal models in vivo. This project aims at: - completing our knowledge
Involvement of the DnaJ co-chaperon in prophage excision – ChapEx
improves this reaction in vivo, using a physiological approach as well as in vitro using a site-specific [...] . Interestingly, we further showed using an in vitro recombination system that DnaJ can favour the excision
Joint research laboratory for evaluating the potential of algae in anti-infectious health in livestock production – ALGAHEALTH
s. The UMR-ISP has developed several in vitro and in vivo tools and analysis models recognized by the [...] of bioactive ingredients (AMADEITE), - The in vitro screening of these bioactive compounds by growth
Contrôle spatio-temporel de la ségrégation des chromosomes – CHROMALIGN
mechanism is conserved for human Cenp-E, both in vitro and in vivo. This required the characterisation of the [...] and/or CDK1-cyclin B dependent phosphorylation in vitro (Espeut et al., 2008). The next obvious steps are [...] understand whether this mechanism is conserved in vivo, and also applies to human Cenp-E. In order to fulfil
Ultrafast 4D ultrasound – Ultrafast4D
Ultrasound imaging is widely used in clinical practice for its low cost, high resolution, high frame rate and portability. <br />In the last decade, the introduction of ultrafast imaging has enabled new acquisition modes such as shear wave elastography, 3D imaging systems have enabled volume acquisition but at much lower framerates. <br /><br />We believe ultrafast 4D ultrasound imaging is key issue for the development of new diagnostic applications in the next decades for the benefit of patients.
Multiscale functional imaging in the central nervous system – MULTISCALEFUNIM
the technology is operative currently only in in-vitro thin brain slice preparation. Being able to bring [...] bring full 3D microscopic technique to in vivo imaging, in particular in large-brain mammals such as rodents [...] able to image the activity of small networks in vivo in animal models of human disease will open the
GENOME-WIDE SEARCH FOR FACTORS THAT CONTROL THE ASSEMBLY OF RNA GRANULES – RNAGRIMP
In vivo, mRNAs are packaged together with regulatory proteins into ribonucleoprotein particles (RNP) [...] considered as a major class of neuronal granules, in vivo study of their function and regulation has lagged [...] dynamically transported to axons have been observed in vivo in zebrafish embryonic neurons (F. Giudicelli,
Imaging and modeling the Bacterial Mitosis – IBM
Bacterial DNA segregation involves the directed movement and positioning of chromosomes to accurately distribute them to daughter cells during cell division.<br />Our aim is to answer two specific and challenging questions: (1) What are the in vivo architecture, molecular composition and dynamics of segrosomes? and (2) What is the mechanism by which ParA ultrastructures move segrosomes in vivo?
Polyion complex micelles for siRNA delivery in immature dendritic cells: polymeric vectors for ex vivo gene silencing in arthritis. – DenSicelles
Our study consists of developping a vector able to release small interferent RNA to reinforce the tolerogenic potential of dendritic cells. These modified cells will make possible to restore the control of the immune response.